Impact of diabetes mellitus on cardiac sympathetic innervetion in patients with heart failure: A 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study (Articolo in rivista)

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  • Impact of diabetes mellitus on cardiac sympathetic innervetion in patients with heart failure: A 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.2337/dc12-2147 (literal)
Alternative label
  • Stefania Paolillo, Giuseppe Rengo, Gennaro Pagano, Teresa Pellegrino, Gianluigi Savarese, Grazia D. Femminella, Marianna Tuccillo, Antonio Boemio, Emilio Attena, Roberto Formisano, Laura Petraglia, Francesco Scopacasa, Gennaro Galasso, Dario Leosco, Bruno Trimarco, Alberto Cuocolo, Pasquale Perrone-Filardi. (2013)
    Impact of diabetes mellitus on cardiac sympathetic innervetion in patients with heart failure: A 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study
    in Diabetes care (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Stefania Paolillo, Giuseppe Rengo, Gennaro Pagano, Teresa Pellegrino, Gianluigi Savarese, Grazia D. Femminella, Marianna Tuccillo, Antonio Boemio, Emilio Attena, Roberto Formisano, Laura Petraglia, Francesco Scopacasa, Gennaro Galasso, Dario Leosco, Bruno Trimarco, Alberto Cuocolo, Pasquale Perrone-Filardi. (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Advanced Biomedical Sciences, Section of Cardiology, Federico II University, Naples, Italy Division of Cardiology, Salvatore Maugeri Foundation, IRCCS, Institute of Telese Terme, Telese Terme (BN), Italy Department of Translational Medical Sciences, Section of Geriatrics, Federico II University, Naples, Italy Department of Advanced Biomedical Sciences, Section of Imaging, Radiotherapy, Neuroradiology, and Medical Physics, Federico II University, Naples, Italy Institute of Biostructures and Bioimages of the National Council of Research, Naples, Italy Department of Cardiology, Fatebenefratelli Hospital, Naples, Italy Department of Molecular Medicine and Medical Biotechnologies, Federico II University, Naples, Italy SDN Foundation, Institute of Diagnostic and Nuclear Development, Naples, Italy (literal)
Titolo
  • Impact of diabetes mellitus on cardiac sympathetic innervetion in patients with heart failure: A 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study (literal)
Abstract
  • OBJECTIVE Impaired parasympathetic and sympathetic nervous system activity have been demonstrated in patients with diabetes mellitus (DM) and correlated with worse prognosis. Few data are available on the effect of DM on cardiac neuropathy in heart failure (HF). The aim of the current study was to assess cardiac sympathetic activity in HF patients with and without DM. RESEARCH DESIGN AND METHODS Patients with severe HF (n = 75), with (n = 37) and without DM (n = 38), and 14 diabetic patients with normal cardiac function underwent 123I meta-iodobenzylguanidine scintigraphy from which early and late heart-to-mediastinum (H/M) ratios were calculated. Clinical, echocardiographic, and biochemical data were measured. RESULTS DM compared with non-DM patients showed significantly lower early (1.65 ± 0.21 vs. 1.75 ± 0.21; P < 0.05) and late H/M ratios (1.46 ± 0.22 vs. 1.58 ± 0.24; P < 0.03). Early and late H/M were significantly higher in DM patients without HF (2.22 ± 0.35 and 1.99 ± 0.24, respectively) than HF patients with (P < 0.0001) and without (P < 0.0001) DM. In HF patients, an inverse correlation between early or late H/M ratio and hemoglobin A1c (HbA1c) (Pearson = -0.473, P = 0.001; Pearson = -0.382, P = 0.001, respectively) was observed. In DM, in multivariate analysis, HbA1c and ejection fraction remained significant predictors of early H/M; HbA1c remained the only significant predictor of late H/M. No correlation between early or late H/M and HbA1c was found in non-DM patients. CONCLUSIONS Diabetic patients with HF show lower cardiac sympathetic activity than HF patients not having DM or than DM patients with a similar degree of autonomic dysfunction not having HF. HbA1c correlated with the degree of reduction in cardiac sympathetic activity. (literal)
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