Should patients with remnants from thyroid microcarcinoma really not be treated with iodine-131 ablation? (Articolo in rivista)

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  • Should patients with remnants from thyroid microcarcinoma really not be treated with iodine-131 ablation? (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s12020-013-9935-9 (literal)
Alternative label
  • Gallicchio, Rosj; Giacomobono, Sabrina; Capacchione, Daniela; Nardelli, Anna; Barbato, Francesco; Nappi, Antonio; Pellegrino, Teresa; Storto, Giovanni (2013)
    Should patients with remnants from thyroid microcarcinoma really not be treated with iodine-131 ablation?
    in Endocrine (Basingstoke)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Gallicchio, Rosj; Giacomobono, Sabrina; Capacchione, Daniela; Nardelli, Anna; Barbato, Francesco; Nappi, Antonio; Pellegrino, Teresa; Storto, Giovanni (literal)
Pagina inizio
  • 426 (literal)
Pagina fine
  • 433 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 44 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
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  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CROB; Consiglio Nazionale delle Ricerche (CNR) (literal)
Titolo
  • Should patients with remnants from thyroid microcarcinoma really not be treated with iodine-131 ablation? (literal)
Abstract
  • Remnant ablation by radioiodine is generally not recommended in patients presenting uni- or multifocal cancer < 1 cm, in the absence of other higher risk features. We retrospectively studied low-risk patients (pts) with differentiated thyroid cancer (DTC) less than 1 cm recruited for radioiodine therapy (RAI). Methods: 91 pts (79 women, age 48.4 +/- A 12 yrs) with DTC were enrolled for RAI. Patients underwent pre-therapy ultrasonography (US), those with suspected/ambiguous lymph-nodes were excluded and proposed for cytology. Treated pts underwent post-therapeutic whole body scan (WBSt) completed by neck/chest SPECT/CT, when necessary (e.g. evidence of uptake outside of thyroid bed). A target lesion on SPECT/CT was defined as an identifiable lymph-nodal site presenting a matched significant iodine uptake. The patients were followed up for 14 +/- A 2 months thereafter. Results: All pts/cancers were pT1. The mean histological diameter was 0.68 +/- A 0.23 cm. Six patients were excluded because of suspected nodal involvement at US. Thirty (35 %) out of 85 pts had suspicious WBSt as per lymph-nodal involvement which was confirmed at the subsequent SPECT/CT acquisition in most part of pts (26/30; 86 %). Overall detected target lesions was 34, and nine (26 %) had interim positive fine needle cytology. Conclusions: a significant part of low risk DTC patients, for whom RAI is not recommended, presents an incidental suspicion of lymph-nodal involvement at WBSt confirmed by subsequent SPECT/CT. Such setting would have not been treated by I-131. (literal)
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