Imaging characterization of benign and malignant pheochromocytoma or paraganglioma: comparison between MIBG uptake and MR signal intensity ratio (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Imaging characterization of benign and malignant pheochromocytoma or paraganglioma: comparison between MIBG uptake and MR signal intensity ratio (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s12149-012-0624-1 (literal)

Alternative label

• Simone Maurea o Alberto Cuocolo o Massimo Imbriaco o Teresa Pellegrino o Mario Fusari o Renato Cuocolo o Raffaele Liuzzi o Marco Salvatore (2012)
  Imaging characterization of benign and malignant pheochromocytoma or paraganglioma: comparison between MIBG uptake and MR signal intensity ratio
  in Annals of nuclear medicine
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Simone Maurea o Alberto Cuocolo o Massimo Imbriaco o Teresa Pellegrino o Mario Fusari o Renato Cuocolo o Raffaele Liuzzi o Marco Salvatore (literal)

Pagina inizio

• 670 (literal)

Pagina fine

• 675 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 26 (literal)

Rivista

• Annals of nuclear medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Biomorphological and Functional Sciences, University Federico II, Naples, Italy. Istituto di Biostrutture e Bioimmagini - CNR, Napoli (literal)

Titolo

• Imaging characterization of benign and malignant pheochromocytoma or paraganglioma: comparison between MIBG uptake and MR signal intensity ratio (literal)

Abstract

• OBJECTIVE: We compared metaiodobenzylguanidine (MIBG) uptake and magnetic resonance (MR) signal intensity ratio in differentiating benign and malignant disease in patients with pheochromocytoma or paraganglioma. METHODS: Eighteen patients (9 men, mean age 37 ± 8 years) with pheochromocytoma or paraganglioma underwent MR imaging and iodine-131 MIBG scintigraphy. MR signal intensity ratio was measured on T1 and T2-weighted images using region of interest analysis and intensity ratio of MIBG uptake was calculated for each tumor lesion on 48 h images. RESULTS: A total of 28 tumor lesions was analyzed of which 12 were benign and 16 malignant. MIBG uptake intensity ratio was significantly higher in malignant lesions compared to benign (5.2 ± 2.4 and 2.9 ± 1.4, respectively, p < 0.01). On the contrary, no significant difference in tumor size and MR signal intensity ratio between malignant and benign tumor lesions was observed. CONCLUSIONS: In patients with pheochromocytoma or paraganglioma, iodine-131 MIBG uptake is able to differentiate between benign and malignant disease, while MR imaging is not useful for this purpose. The higher MIBG uptake observed in malignant lesions could reflect major tumor storage of catecholamines compared to benign lesions. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Imaging Morfo-funzionale Integrato delle Patologie del Distretto Toraco-addominale e Sviluppo di Sistemi Integrati di Gestione e Trasmissione di Dati (ME.P06.003.001) (Modulo)

Autore CNR

• TERESA PELLEGRINO (Unità di personale interno)
• MASSIMO IMBRIACO (Unità di personale esterno)
• MARCO SALVATORE (Persona)
• ALBERTO CUOCOLO (Persona)
• RAFFAELE LIUZZI (Unità di personale interno)

Incoming links:

Autore CNR di

• RAFFAELE LIUZZI (Unità di personale interno)
• ALBERTO CUOCOLO (Persona)
• MARCO SALVATORE (Persona)
• TERESA PELLEGRINO (Unità di personale interno)
• MASSIMO IMBRIACO (Unità di personale esterno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Imaging Morfo-funzionale Integrato delle Patologie del Distretto Toraco-addominale e Sviluppo di Sistemi Integrati di Gestione e Trasmissione di Dati (ME.P06.003.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Annals of nuclear medicine (Rivista)