Epilepsy and brain abnormalities in mice lacking the Otx1 gene. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Epilepsy and brain abnormalities in mice lacking the Otx1 gene. (Articolo in rivista) (literal)

Anno

• 1996-01-01T00:00:00+01:00 (literal)

Alternative label

• Acampora D., Mazan S., Avantaggiato V., Barone P., Tuorto F., Lallemand Y., Brûlet P. & Simeone A. (1996)
  Epilepsy and brain abnormalities in mice lacking the Otx1 gene.
  in Nature genetics (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Acampora D., Mazan S., Avantaggiato V., Barone P., Tuorto F., Lallemand Y., Brûlet P. & Simeone A. (literal)

Pagina inizio

• 218 (literal)

Pagina fine

• 221 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 14 (literal)

Rivista

• Nature genetics (Rivista)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• International Institute of Genetics and Biophysics, CNR, Via G. Marconi 12, 80125 Naples, Italy Unité d'Embryologie Moléculaire, URA 1947 du CNRS, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France Department of Neurological Sciences, University of Naples \"Federico II,\" Via S.Pansini5, 80131 Naples, Italy (literal)

Titolo

• Epilepsy and brain abnormalities in mice lacking the Otx1 gene. (literal)

Abstract

• The morphogenesis of the brain and the differentiation of the neural structures are highly complex processes. A series of temporally and spatially regulated morphogenetic events gives rise to smaller areas that are phylogenetically, functionally and often morphogenetically different. Candidate genes for positional information and differentiation during morphogenesis have been isolated. Both in vivo inactivation in mice and impairment in human diseases revealed, that they are required in regional specification and/or correct cell-type induction. We have previously cloned and characterized the murine Otx1 gene, which is related to orthodenticle (otd), a homeobox-containing gene required for Drosophila head development. Expression data during murine embryogenesis and postnatal brain development support the idea that Otx1 could be required for correct brain and sense organs development. To decipher its role in vivo we produced null mice by replacing Otx1 with the lacZ gene. Otx1-/- mice showed spontaneous epileptic behaviour and multiple abnormalities affecting mainly the telencephalic temporal and perirhinal areas, the hippocampus, the mesencephalon and the cerebellum, as well as the acoustic and visual sense organs. Our findings indicate that the Otx1 gene product is required for proper brain functions. (literal)

Prodotto di

• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• VIRGINIA AVANTAGGIATO (Unità di personale interno)
• FRANCESCA TUORTO (Persona)
• DARIO ACAMPORA (Persona)
• ANTONIO SIMEONE (Persona)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)

Autore CNR di

• ANTONIO SIMEONE (Persona)
• VIRGINIA AVANTAGGIATO (Unità di personale interno)
• DARIO ACAMPORA (Persona)
• FRANCESCA TUORTO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nature genetics (Rivista)