Synthesis and molecular modeling of novel HSV1 uracil-DNA glycosylase inhibitors. (Articolo in rivista)

Type
Label
  • Synthesis and molecular modeling of novel HSV1 uracil-DNA glycosylase inhibitors. (Articolo in rivista) (literal)
Anno
  • 1999-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pregnolato M, Ubiali D, Verri A, Focher F, Spadari S, Sun H, Zhi C, Wright GE. (1999)
    Synthesis and molecular modeling of novel HSV1 uracil-DNA glycosylase inhibitors.
    in Nucleosides & nucleotides
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pregnolato M, Ubiali D, Verri A, Focher F, Spadari S, Sun H, Zhi C, Wright GE. (literal)
Pagina inizio
  • 709 (literal)
Pagina fine
  • 711 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 18 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Genetica Molecolare, CNR, Pavia (literal)
Titolo
  • Synthesis and molecular modeling of novel HSV1 uracil-DNA glycosylase inhibitors. (literal)
Abstract
  • In a recent paper the first selective inhibitors of HSV1 uracil-DNA glycosylase (UDG) acting in the micromolar range have been reported. A 28.5 kDa catalytic fragment of HSV1 UDG has been crystallized in the presence of uracil, and the structure was recently solved. Starting with the optimized model of binding between 6-(4'-n-octylanilino)uracil (octAU) and UDG some new derivatives have been predicted to be active. In vitro studies with the novel synthetized compounds confirm the plausibility of the model and define the structure features for UDG inhibitors. (literal)
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