Condensation anomalies and exclusion in micronuclei of rearranged chromosomes in human fibroblasts cultured in vitro (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Condensation anomalies and exclusion in micronuclei of rearranged chromosomes in human fibroblasts cultured in vitro (Articolo in rivista) (literal)

Anno

• 1995-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/BF00347696 (literal)

Alternative label

• Casati A, Riboni R, Caprioli J, Nuzzo F, Mondello C. (1995)
  Condensation anomalies and exclusion in micronuclei of rearranged chromosomes in human fibroblasts cultured in vitro
  in Chromosoma (Berl., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Casati A, Riboni R, Caprioli J, Nuzzo F, Mondello C. (literal)

Pagina inizio

• 137 (literal)

Pagina fine

• 142 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 104 (literal)

Rivista

• Chromosoma (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Casati A, Riboni R, Caprioli J, Nuzzo F, Mondello C: Istituto di Geentica Molecolare, CNR, Pavia (literal)

Titolo

• Condensation anomalies and exclusion in micronuclei of rearranged chromosomes in human fibroblasts cultured in vitro (literal)

Abstract

• Anomalies of chromatin condensation, such as fragmentation, uncoiling and pulverization, were observed in XP9UV25, a xeroderma pigmentosum fibroblast clone in which a high proportion of cells carried an end-to-end dicentric chromosome, dic (5;16) (p15.2;q24), that gives rise during propagation in culture to a variety of dicentric and monocentric derivatives. The coiling anomaly affected exclusively part of a rearranged chromosome, in particular the region previously involved in breakage events. The heterochromatic 16q region, which is a preferential breakpoint in the formation of dicentric and monocentric derivatives, was consistently the limit of the uncoiled or pulverized regions. This observation suggests that the anomalous chromatin behavior could derive from alteration of a region relevant for the correct condensation of the chromosome. In XP9UV25 the frequency of nuclei with associated micronuclei increased with time in culture, in parallel with that of mitoses with dicentric chromosomes. In situ hybridization with DNA probes specific for chromosomes 5 and 16 revealed hybridization signals in about 40% of micronuclei. Since the frequency of micronuclei is about ten times less than that of dicentrics, it is probable that only the rearranged chromosomes undergoing coiling anomalies are excluded in micronuclei. (literal)

Prodotto di

• Institute of molecular genetics (IGM) (Istituto)
• Studio di pathway coinvolti nella progressione tumorale (ME.P05.005.002) (Modulo)

Autore CNR

• CHIARA MONDELLO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Condensation anomalies and exclusion in micronuclei of rearranged chromosomes in human fibroblasts cultured in vitro" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Studio di pathway coinvolti nella progressione tumorale (ME.P05.005.002) (Modulo)

Autore CNR di

• CHIARA MONDELLO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Chromosoma (Rivista)

Insieme di parole chiave di

• Parole chiave di "Condensation anomalies and exclusion in micronuclei of rearranged chromosomes in human fibroblasts cultured in vitro" (Insieme di parole chiave)