The effect on survival of bone marrow and blood involvement in non-Hodgkin's lymphoma (NHL). A retrospective study of 962 cases. (Abstract/Poster in rivista)

Type
Label
  • The effect on survival of bone marrow and blood involvement in non-Hodgkin's lymphoma (NHL). A retrospective study of 962 cases. (Abstract/Poster in rivista) (literal)
Anno
  • 1993-01-01T00:00:00+01:00 (literal)
Alternative label
  • Lazzarino M, Morra E, Castello A, Pagnucco G, Brusamolino E, Santagostino A, Corso A, Lisa A, Zei G, Bernasconi C. (1993)
    The effect on survival of bone marrow and blood involvement in non-Hodgkin's lymphoma (NHL). A retrospective study of 962 cases.
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Lazzarino M, Morra E, Castello A, Pagnucco G, Brusamolino E, Santagostino A, Corso A, Lisa A, Zei G, Bernasconi C. (literal)
Pagina fine
  • 2266 (literal)
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  • 82 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 10 (literal)
Note
  • Poster (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IGM-CNR; Institute and Division of Hematology, Section of Pathology, University of Pavia; IRCCS Policlinico San Matteo. (literal)
Titolo
  • The effect on survival of bone marrow and blood involvement in non-Hodgkin's lymphoma (NHL). A retrospective study of 962 cases. (literal)
Abstract
  • In a series of 962 pts with NHL classified according to the Working Formulation we evaluated the long-term prognostic effect of bone marrow (BM+) and peripheral blood (PB+) involvement, present at diagnosis (early) or occurring during the course of the disease (late). BM+ was detected at diagnosis in 343 patients (36%): in 213/407 (52%) low-grade (LG), in 74/299 (25%) intermediate-grade (IG), and in 56/256 (22%) high-grade (HG) NHL (LG vs. IG and HG, P<0.0001). Late BM+ was found in 39 further patients (4%): 11 LG, 11 IG, and 17 HG-NHL. PB+ was present at diagnosis in 104 pts (11%): in 16% of LG, 6% of IG (LG vs. IG P< 0l.001), 9% of HG-NHL (LG vs HG P<0.01). A late leukemic phase occurred in 69 pts (7%): 24 LG, 20 IG, snd 25 HL-NHL. The median survival was 95 mos for LG-, 52 mos for IG-, and 18 mos for HG-NHL. In LG-NHL, BM+ and PB+ BM+ at diagnosis did not affect the outcome, while the occurrence of BM+ and PB+ during the course of the disease carried a worse prognosis. In IG-NHL and HG-NHL, either initial or subsequent BM+ and PB+ were correlated with significantly shorter survival. (literal)
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