Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. (Articolo in rivista) (literal)

Anno

• 1990-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/346763a0 (literal)

Alternative label

• Simeone, A., Acampora, D., Arcioni, L., Andrews, P.W., Boncinelli, E. & Mavilio, F. (1990)
  Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells.
  in Nature (Lond.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Simeone, A., Acampora, D., Arcioni, L., Andrews, P.W., Boncinelli, E. & Mavilio, F. (literal)

Pagina inizio

• 763 (literal)

Pagina fine

• 766 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 346 (literal)

Rivista

• Nature (Rivista)

Note

• ISI Web of Science (WOS) (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• International Institute of Genetics and Biophysics, CNR, Via Marconi 10, 80125 Napoli, Italy Istituto Scientifico H. S. Raffaele, Via Olgettina 60, 20132 Milano, Italy The Wistar Institute, 36th and Spruce Streets, Philadelphia, Pennsylvania 19104, USA (literal)

Titolo

• Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. (literal)

Abstract

• RETINOIC acid has been implicated as a natural morphogen in chicken1-4 and frog5 embryogenesis, and is presumed to act through the gene regulatory activity of a family of nuclear receptors6-10. Homeobox genes, which specify positional information in Drosophila and possibly in vertebrate embryogenesis11-21, are among the candidate responsive genes4,5,14. We previously reported that retinoic acid specifically induces human homeobox gene (HOX) expression in the embryonal carcinoma cell line NT2/D1 (ref. 22). We now show that the nine genes of the HOX2 cluster are differentially activated in NT2/D1 cells exposed to retinoic acid concentrations ranging from 10-8 to 10-5 M. Genes located in the 3' half of the cluster are induced at peak levels by 10-8 M retinoic acid, whereas a concentration of 10-6 to 10-5 M is required to fully activate 5' genes. At both high and low retinoic acid concentrations, HOX2 genes are sequentially activated in embryonal carcinoma cells in the 3' to 5' direction. (literal)

Prodotto di

• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• ANTONIO SIMEONE (Persona)
• EDOARDO BONCINELLI (Unità di personale interno)
• DARIO ACAMPORA (Persona)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)

Autore CNR di

• ANTONIO SIMEONE (Persona)
• DARIO ACAMPORA (Persona)
• EDOARDO BONCINELLI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nature (Rivista)