miR-191 Down-Regulation Plays a Role in Thyroid Follicular Tumors through CDK6 Targeting. (Articolo in rivista)

Type
Label
  • miR-191 Down-Regulation Plays a Role in Thyroid Follicular Tumors through CDK6 Targeting. (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Colamaio M, Borbone E, Russo L, Bianco M, Federico A, Califano D, Chiappetta G, Pallante P, Troncone G, Battista S, Fusco A. (2011)
    miR-191 Down-Regulation Plays a Role in Thyroid Follicular Tumors through CDK6 Targeting.
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Colamaio M, Borbone E, Russo L, Bianco M, Federico A, Califano D, Chiappetta G, Pallante P, Troncone G, Battista S, Fusco A. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 9 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • miR-191 Down-Regulation Plays a Role in Thyroid Follicular Tumors through CDK6 Targeting. (literal)
Abstract
  • Context:Well-differentiated thyroid carcinomas include papillary (PTC) and follicular (FTC) carcinomas. FTC is usually a more aggressive form of cancer than the more common papillary type. miR-191 expression is frequently altered in several neoplasias, being up-regulated in some cases, such as pancreatic carcinomas, and down-regulated in other carcinomas, such as melanomas.Objective:The objective was to evaluate the expression and the role of miR-191 in thyroid carcinogenesis.Design:The expression of miR-191 was analyzed in tissues from patients with follicular adenoma (n = 24), FTC (n = 24), PTC (n = 15), anaplastic thyroid carcinoma (n = 8), and the follicular variant of PTC (n = 6) compared with normal thyroid tissues by quantitative RT-PCR. miR-191 expression was restored in the follicular thyroid cell line WRO, and the effects on cell proliferation, migration, and target expression were evaluated.Results:miR-191 is down-regulated in follicular adenoma, FTC, and follicular variant of PTC. We identified CDK6, a serine-threonine kinase involved in the control of cell cycle progression, as a novel target of miR-191. Restoration of miR-191 expression in WRO cells reduces cell growth and migration rate on vitronectin. CDK6 overexpression, correlated with miR-191 down-regulation, was found in follicular adenoma and FTC, suggesting a role of miR-191 down-regulation in the generation of these neoplasias.Conclusions:Our results suggest that miR-191 down-regulation plays a role in thyroid neoplasias of the follicular histotype, likely by targeting CDK6. (literal)
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