High Mobility Group A1 (HMGA1) proteins regulate p53-mediated transcription of Bcl-2 gene. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• High Mobility Group A1 (HMGA1) proteins regulate p53-mediated transcription of Bcl-2 gene. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Esposito F; Tornincasa M; Chieffi P; De Martino I; Pierantoni GM; Fusco A. (2010)
  High Mobility Group A1 (HMGA1) proteins regulate p53-mediated transcription of Bcl-2 gene.
  in Cancer research (Chic. Ill.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Esposito F; Tornincasa M; Chieffi P; De Martino I; Pierantoni GM; Fusco A. (literal)

Pagina inizio

• 5379 (literal)

Pagina fine

• 5388 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 70 (literal)

Rivista

• Cancer research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli \"Federico II\", Dipartimento di Medicina Sperimentale, Seconda Università di Napoli, and Naples Oncogenomic Center-Centro di Ingegneria Genetica, Biotecnologie Avanzate-Napoli, and the European School of Molecular Medicine, Naples, Italy (literal)

Titolo

• High Mobility Group A1 (HMGA1) proteins regulate p53-mediated transcription of Bcl-2 gene. (literal)

Abstract

• We have previously described a mechanism through which the high-mobility group A1 (HMGA1) proteins inhibit p53-mediated apoptosis by delocalizing the p53 proapoptotic activator homeodomain-interacting protein kinase 2 from the nucleus to the cytoplasm. By this mechanism, HMGA1 modulates the transcription of p53 target genes such as Mdm2, p21(waf1), and Bax, inhibiting apoptosis. Here, we report that HMGA1 antagonizes the p53-mediated transcriptional repression of another apoptosis-related gene, Bcl-2, suggesting a novel mechanism by which HMGA1 counteracts apoptosis. Moreover, HMGA1 overexpression promotes the reduction of Brn-3a binding to the Bcl-2 promoter, thereby blocking the Brn-3a corepressor function on Bcl-2 expression following p53 activation. Consistently, a significant direct correlation between HMGA1 and Bcl-2 overexpression has been observed in human breast carcinomas harboring wild-type p53. Therefore, this study suggests a novel mechanism, based on Bcl-2 induction, by which HMGA1 overexpression contributes to the escape from apoptosis leading to neoplastic transformation. Copyright 2010 AACR. (literal)

Prodotto di

• Ruolo delle proteine cromatiniche nella tumorigenesi (SV.P15.001.002) (Modulo)
• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• GIOVANNA MARIA PIERANTONI (Persona)
• Francesco Esposito (Persona)
• ALFREDO FUSCO (Persona)
• ALFREDO FUSCO (Unità di personale interno)

Incoming links:

Autore CNR di

• ALFREDO FUSCO (Unità di personale interno)
• ALFREDO FUSCO (Persona)
• GIOVANNA MARIA PIERANTONI (Persona)
• Francesco Esposito (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Ruolo delle proteine cromatiniche nella tumorigenesi (SV.P15.001.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cancer research (Rivista)