http://www.cnr.it/ontology/cnr/individuo/prodotto/ID212822
Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses. (Articolo in rivista)
- Type
- Label
- Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses. (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Alternative label
Matarese G, Procaccini C, Menale C, Kim JG, Kim JD, Diano S, Diano N, De Rosa V, Dietrich MO, Horvath TL. (2013)
Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses.
in Proceedings of the National Academy of Sciences of the United States of America
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Matarese G, Procaccini C, Menale C, Kim JG, Kim JD, Diano S, Diano N, De Rosa V, Dietrich MO, Horvath TL. (literal)
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, 84081 Salerno, Italy. (literal)
- Titolo
- Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses. (literal)
- Abstract
- Whole-body energy metabolism is regulated by the hypothalamus and has an impact on diverse tissue functions. Here we show that selective knockdown of Sirtuin 1 Sirt1 in hypothalamic Agouti-related peptide-expressing neurons, which renders these cells less responsive to cues of low energy availability, significantly promotes CD4(+) T-cell activation by increasing production of T helper 1 and 17 proinflammatory cytokines via mediation of the sympathetic nervous system. These phenomena were associated with an impaired thymic generation of forkhead box P3 (FoxP3(+)) naturally occurring regulatory T cells and their reduced suppressive capacity in the periphery, which resulted in increased delayed-type hypersensitivity responses and autoimmune disease susceptibility in mice. These observations unmask a previously unsuspected role of hypothalamic feeding circuits in the regulation of adaptive immune response. (literal)
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