http://www.cnr.it/ontology/cnr/individuo/prodotto/ID21258
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells. (Articolo in rivista)
- Type
- Label
- The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells. (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
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- Melillo RM; Castellone MD; Guarino V; De Falco V; Cirafici AM; Salvatore G; Caiazzo F; Basolo F; Giannini R; Kruhoffer M; Orntoft T; Fusco A; Santoro M. (literal)
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- Rivista
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Melillo RM; Castellone MD; Guarino V; De Falco V; Cirafici AM; Salvatore G; Caiazzo F, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR \"G. Salvatore,\" Dipartimento di Biologia e Patologia Cellulare e Molecolare, University \"Federico II,\" Naples, Italy;
Basolo F; Giannini R, Dipartimento di Oncologia, Universita? di Pisa, Pisa, Italy;
Kruhoffer M; Orntoft T, Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Aarhus, Denmark;
Fusco A; Santoro M, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR \"G. Salvatore,\" Dipartimento di Biologia e Patologia Cellulare e Molecolare, University \"Federico II,\" Naples, Italy; (literal)
- Titolo
- The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells. (literal)
- Abstract
- In papillary thyroid carcinomas (PTCs), rearrangements of the RET receptor (RET/PTC) and activating mutations
in the BRAF or RAS oncogenes are mutually exclusive. Here we show that the 3 proteins function along a
linear oncogenic signaling cascade in which RET/PTC induces RAS-dependent BRAF activation and RAS- and
BRAF-dependent ERK activation. Adoptive activation of the RET/PTC-RAS-BRAF axis induced cell proliferation
and Matrigel invasion of thyroid follicular cells. Gene expression profiling revealed that the 3 oncogenes
activate a common transcriptional program in thyroid cells that includes upregulation of the CXCL1 and
CXCL10 chemokines, which in turn stimulate proliferation and invasion. Thus, motile and mitogenic properties
are intrinsic to transformed thyroid cells and are governed by an epistatic oncogenic signaling cascade. (literal)
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