http://www.cnr.it/ontology/cnr/individuo/prodotto/ID21255
Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness. (Articolo in rivista)
- Type
- Label
- Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness. (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Alternative label
Celetti A, Testa D, Staibano S, Merolla F, Guarino V, Castellone MD, Iovine R, Mansueto G, Somma P, De Rosa G, Galli V, Melillo RM, Santoro M. (2005)
Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness.
in Clinical cancer research (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Celetti A, Testa D, Staibano S, Merolla F, Guarino V, Castellone MD, Iovine R, Mansueto G, Somma P, De Rosa G, Galli V, Melillo RM, Santoro M. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche/Dipartimento di Biologia e Patologia Cellulare e Molecolare, Dipartimento Assistenziale di Otorinolaringoiatria e Scienze Affini, and Dipartimento di Scienze Biomorfologiche e Funzionali, University of Naples ''Federico II,'' Naples, Italy (literal)
- Titolo
- Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness. (literal)
- Abstract
- Purpose: Osteopontin is a secreted cytokine that binds to the cell surface CD44v6 receptor.
We studied osteopontin and CD44v6 expression in laryngeal squamous cell carcinomas and
correlated osteopontin expression levels with clinicopathologic tumor features.
Experimental Design:We used immunohistochemistry, immunoblotting, and reverse transcription-
PCR to study osteopontin expression in 58 laryngeal squamous cell carcinomas. Cultured
squamous carcinoma cells were treated with exogenous osteopontin or with RNA interference
to knockdown osteopontin expression.
Results: Osteopontin expression was higher in all the invasive carcinomas than in patientmatched
normalmucosa. Its expression levels were significantly correlated with tumor stage and
grade and with the presence of lymph node and distant metastases. Osteopontin positivity was
negatively correlated with overall survival (P = 0.03). Osteopontin expression was paralleled by
intense cell surface reactivity for CD44v6.Treatment of squamous carcinoma cells with recombinant
osteopontin sharply increased proliferation and Matrigel invasion in comparison with the
untreated cells parallel to activation of the mitogen-activated protein kinase/extracellular signalregulated
kinase kinase/mitogen-activated protein kinase signaling cascade. Osteopontin
knockdown by RNA interference, anti-CD44 antibodies, and mitogen-activated protein kinase/
extracellular signal-regulated kinase kinase inhibition prevented these effects.
Conclusions:These results identify osteopontin as amarker and a potential therapeutic target in
cases of aggressive laryngeal squamous cell carcinomas. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi