Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase (Articolo in rivista)

Type
Label
  • Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1371/journal.pbio.0030123.g003 (literal)
Alternative label
  • Laura Cerchia 1; Frederic Duconge 2; Carine Pestourie 2; Jocelyne Boulay 3; Youssef Aissouni 3; Karine Gombert 2; Bertrand Tavitian 2; Vittorio de Franciscis 1; Domenico Libri 3 (2005)
    Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase
    in PLoS biology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Laura Cerchia 1; Frederic Duconge 2; Carine Pestourie 2; Jocelyne Boulay 3; Youssef Aissouni 3; Karine Gombert 2; Bertrand Tavitian 2; Vittorio de Franciscis 1; Domenico Libri 3 (literal)
Pagina inizio
  • 697 (literal)
Pagina fine
  • 704 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 3 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 4 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Istituto per I'Endocrinologia e Oncologia Molecolare ''G. Salvatore'', CNR, Naples, Italy, 2 CEA/DSV/DRM Service Hospitalier Fre´de´ ric Joliot, INSERM E-103, Orsay, France, 3 Centre de Ge´ne´tique Mole´culaire, Centre National de la Recherche Scientifique (CNRS), Gif sur Yvette, France (literal)
Titolo
  • Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase (literal)
Abstract
  • Targeting large transmembrane molecules, including receptor tyrosine kinases, is a major pharmacological challenge. Specific oligonucleotide ligands (aptamers) can be generated for a variety of targets through the iterative evolution of a random pool of sequences (SELEX). Nuclease-resistant aptamers that recognize the human receptor tyrosine kinase RET were obtained using RET-expressing cells as targets in a modified SELEX procedure. Remarkably, one of these aptamers blocked RET-dependent intracellular signaling pathways by interfering with receptor dimerization when the latter was induced by the physiological ligand or by an activating mutation. This strategy is generally applicable to transmembrane receptors and opens the way to targeting other members of this class of proteins that are of major biomedical importance. (literal)
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