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Impact of percent body fat on oral glucose tolerance testing: A cross-sectional study in 1512 obese children (Articolo in rivista)

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Impact of percent body fat on oral glucose tolerance testing: A cross-sectional study in 1512 obese children (Articolo in rivista) (literal)

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Bedogni, G ; Gastaldelli, A ; Agosti, F ; De Col, A; Marazzi, N ; Mazzilli, G ; Saezza, A ; Sartorio, A (2012)
Impact of percent body fat on oral glucose tolerance testing: A cross-sectional study in 1512 obese children
in Journal of endocrinological investigation (Testo stamp.); Kurtis, Milano (Italia)
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Bedogni, G ; Gastaldelli, A ; Agosti, F ; De Col, A; Marazzi, N ; Mazzilli, G ; Saezza, A ; Sartorio, A (literal)

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[ 1 ] Ctr Studi Fegato, Unita Epidemiol Clin, I-34012 Trieste, Italy [ 2 ] CNR, Ist Fisiol Clin, Pisa, Italy [ 3,4,5,8 ] IRCCS, Ist Auxol Italiano, Lab Sperimentale Ric Auxoendocrinol, Milan, Italy [ 3,4,5,8 ] IRCCS, Ist Auxol Italiano, Lab Sperimentale Ric Auxoendocrinol, Oggebbio, Verbania, Italy [ 6,7,8 ] IRCCS, Ist Auxol Italiano, Div Auxol, Oggebbio, Verbania, Italy (literal)

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Impact of percent body fat on oral glucose tolerance testing: A cross-sectional study in 1512 obese children (literal)

Abstract

Background: Although an association between insulin resistance (IR) and body adiposity has been reported in obese children, this relationship has not been studied as thoroughly as in adults. Aim: We evaluated the association between oral glucose tolerance testing (OGTT) and percent body fat (PBF) in a sample of 1512 obese children followed at a Pediatric Obesity Clinic. Subjects and methods: Six hundred and twenty-eight male and 884 female obese children aged 6 to 18 yr were consecutively enrolled into the study. OGTT was performed with administration of 1.75 g of glucose per kg of body weight (up to 75 g). PBF was estimated through bioelectrical impedance analysis (BIA) using a population-specific formula recently published by our group. Multivariable median regression was used to evaluate the association between 4 outcomes [glucose area under the curve (AUC), insulin AUC, insulin sensitivity index (151), and insulinogenic index (IGI)] and gender, age or pubertal status and PBF. Results: Median PBF was 52% (range 26 to 70%). After correction for age and gender, a 10% increase of PBF was associated with a decrease of -0.50 [95% confidence interval (Cl): -0.65 to -0.35] units of ISI and an increase of 0.15 units of IGI (95%Cl 0.07 to 0.24). Conclusions: In obese children, PBF is inversely associated with IR and directly associated to beta-cell response as detected by OGTT. (J. Endocrinol. Invest. 35: 893-896, 2012) (C) 2012, Editrice Kurtis (literal)

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