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Gastric bypass and banding equally improve insulin sensitivity and beta cell function (Articolo in rivista)

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Gastric bypass and banding equally improve insulin sensitivity and beta cell function (Articolo in rivista) (literal)

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Bradley, D ; Conte, C; Mittendorfer, B; Eagon, JC ; Varela, JE ; Fabbrini, E ; Gastaldelli, A ; Chambers, KT ; Su, X ; Okunade, A ; Patterson, BW ; Klein, S (2012)
Gastric bypass and banding equally improve insulin sensitivity and beta cell function
in The Journal of clinical investigation; American Society Of Clinical Investigation Inc., Ann Arbor (Stati Uniti d'America)
(literal)

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Bradley, D ; Conte, C; Mittendorfer, B; Eagon, JC ; Varela, JE ; Fabbrini, E ; Gastaldelli, A ; Chambers, KT ; Su, X ; Okunade, A ; Patterson, BW ; Klein, S (literal)

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[ 1,2,3,4,5,6,8,9,10,11,12 ] Washington Univ, Sch Med, Ctr Human Nutr, St Louis, MO 63110 USA [ 2 ] Univ Roma La Sapienza, Dept Clin Med, Rome, Italy [ 7 ] CNR, Inst Clin Physiol, Pisa, Italy (literal)

Titolo

Gastric bypass and banding equally improve insulin sensitivity and beta cell function (literal)

Abstract

Bariatric surgery in obese patients is a highly effective method of preventing or resolving type 2 diabetes mellitus (T2DM); however, the remission rate is not the same among different surgical procedures. We compared the effects of 20% weight loss induced by laparoscopic adjustable gastric banding (LAGB) or Roux-en-Y gastric bypass (RYGB) surgery on the metabolic response to a mixed meal, insulin sensitivity, and beta cell function in nondiabetic obese adults. The metabolic response to meal ingestion was markedly different after RYGB than after LAGB surgery, manifested by rapid delivery of ingested glucose into the systemic circulation, by an increase in the dynamic insulin secretion rate, and by large, early postprandial increases in plasma glucose, insulin, and glucagon-like peptide-1 concentrations in the RYGB group. However, the improvement in oral glucose tolerance, insulin sensitivity, and overall beta cell function after weight loss were not different between surgical groups. Additionally, both surgical procedures resulted in a similar decrease in adipose tissue markers of inflammation. We conclude that marked weight loss itself is primarily responsible for the therapeutic effects of RYGB and LAGB on insulin sensitivity, beta cell function, and oral glucose tolerance in nondiabetic obese adults. (literal)

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