http://www.cnr.it/ontology/cnr/individuo/prodotto/ID212273

Fatty liver index, gamma-glutamyltransferase, and early carotid plaques (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Fatty liver index, gamma-glutamyltransferase, and early carotid plaques (Articolo in rivista) (literal)

Anno

2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1002/hep.25555 (literal)

Alternative label

Kozakova, M ; Palombo, C; Eng, MP ; Dekker, J; Flyvbjerg, A ; Mitrakou, A ; Gastaldelli, A ; Ferrannini, E (2012)
Fatty liver index, gamma-glutamyltransferase, and early carotid plaques
in Hepatology (Baltim. Md.); WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Kozakova, M ; Palombo, C; Eng, MP ; Dekker, J; Flyvbjerg, A ; Mitrakou, A ; Gastaldelli, A ; Ferrannini, E (literal)

Pagina inizio

1406 (literal)

Pagina fine

1415 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.ncbi.nlm.nih.gov/pubmed/22334565 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

55 (literal)

Rivista

Hepatology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

5 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

[ 1,2,8 ] Univ Pisa, Dept Internal Med, I-56122 Pisa, Italy [ 3,7 ] Consiglio Nazl Ric Pisa, Fdn Toscana G Monasterio, Pisa, Italy [ 3,7 ] Consiglio Nazl Ric Pisa, Inst Clin Physiol, Pisa, Italy [ 4 ] EMGO VU Univ Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands [ 5 ] Aarhus Univ, Inst Clin Med, Fac Hlth Sci, Aarhus, Denmark [ 5 ] Aarhus Univ Hosp, Dept Endocrinol & Internal Med, DK-8000 Aarhus, Denmark [6 ] Univ Athens, Diabet & Metab Unit, Dept Clin Therapeut, Athens, Greece (literal)

Titolo

Fatty liver index, gamma-glutamyltransferase, and early carotid plaques (literal)

Abstract

An association between fatty liver and carotid atherosclerosis has been established; however, it is not clear whether this relationship is a consequence of shared conventional risk factors or whether it is determined by specific circulating factors originating from liver or adipose tissue. To identify the factors possibly linking fatty liver and atherosclerosis, we assessed, in 1,012 subjects free of confounding diseases (e.g., hypertension, diabetes, cardiovascular diseases, and dyslipidemia) and metabolic syndrome, the relationship between the presence of early plaques at carotid bifurcation and fatty liver index (FLI; a validated surrogate marker of fatty liver), as well as the associations between carotid plaque presence and established atherosclerotic risk factors, family history of cardiovascular disease (FH-CVD) or diabetes, insulin sensitivity, serum liver enzymes, adipokines, fatty free acids, and high-sensitivity C-reactive protein (hsCRP). A total of 55 of 1,012 subjects (5.4%) had small plaque at carotid bifurcation. Subjects with plaque were older and had higher prevalence of FLI =60 and FH-CVD, higher blood pressure, plasma low-density lipoprotein cholesterol, glucose, gamma-glutamyltransferase (GGT), and hsCRP, as compared to subjects without plaques (P < 0.05). In a logistic regression model, adjusted for sex, liver transaminase, and alcohol consumption, the independent predictors of plaque presence were age (P < 0.0005), FLI =60 (P < 0.0005), and current smoking (P < 0.05). When FLI in the model was replaced by variables used in its equation (e.g., body mass index, waist circumference, plasma triglycerides, and GGT), the independent determinants of plaque presence were age (P < 0.001), GGT (P = 0.001), and current smoking (P < 0.05). Conclusions: Our cross-sectional study suggests that subjects with FLI =60 are at higher risk of atherosclerotic lesions, independently of established risk factors, and that serum GGT may represent a link between fatty liver and the development of early atherosclerosis. (HEPATOLOGY 2012) (literal)

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