http://www.cnr.it/ontology/cnr/individuo/prodotto/ID212235

The ontogeny of the endocrine pancreas in the fetal/newborn baboon (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

The ontogeny of the endocrine pancreas in the fetal/newborn baboon (Articolo in rivista) (literal)

Anno

2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1530/JOE-12-0070 (literal)

Alternative label

Quinn, AR ; Blanco, CL ; Perego, C ; Finzi, G ; La Rosa, S ; Capella, C ; Guardado-Mendoza, R ; Casiraghi, F ; Gastaldelli, A ; Johnson, M ; Dick, EJ ; Folli, F (2012)
The ontogeny of the endocrine pancreas in the fetal/newborn baboon
in Journal of Endocrinology; Bioscientifica Ltd., Bristol (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Quinn, AR ; Blanco, CL ; Perego, C ; Finzi, G ; La Rosa, S ; Capella, C ; Guardado-Mendoza, R ; Casiraghi, F ; Gastaldelli, A ; Johnson, M ; Dick, EJ ; Folli, F (literal)

Pagina inizio

289 (literal)

Pagina fine

299 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.ncbi.nlm.nih.gov/pubmed/22723715 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

214 (literal)

Rivista

Journal of Endocrinology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

3 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

[ 1,2,10 ] Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, Div Neonatol, San Antonio, TX 78229 USA [ 3 ] Univ Milan, Dept Pharmacol & Biomol Sci, I-20134 Milan, Italy [ 4,5,6 ] Osped Circolo Varese, Dept Pathol, Varese, Italy [ 4,5,6 ] Ctr Insubre Biotecnol Salute Umana, I-21100 Varese, Italy [ 4,5,6] Dept Surg & Morphol Sci, I-21100 Varese, Italy [ 7,8,9,12 ] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Diabet Div, San Antonio, TX 78229 USA [ 9 ] CNR, Inst Clin Physiol, I-56126 Pisa, Italy [ 11 ] Texas Biomed Res Inst, San Antonio, TX 78245 USA (literal)

Titolo

The ontogeny of the endocrine pancreas in the fetal/newborn baboon (literal)

Abstract

Erratic regulation of glucose metabolism including hyperglycemia is a common condition in premature infants and is associated with increased morbidity and mortality. The objective of this study was to examine histological and ultrastructural differences in the endocrine pancreas in fetal (throughout gestation) and neonatal baboons. Twelve fetal baboons were delivered at 125 days (d) gestational age (GA), 140d GA, or 175d GA. Eight animals were delivered at term (185d GA); half were fed for 5 days. Seventy-three nondiabetic adult baboons were used for comparison. Pancreatic tissue was studied using light microscopy, confocal imaging, and electron microscopy. The fetal and neonatal endocrine pancreas islet architecture became more organized as GA advanced. The percent areas of alpha-beta-delta-cell type were similar within each fetal and newborn GA (NS) but were higher than the adults (P<0.05) regardless of GA. The ratio of beta cells within the islet (whole and core) increased with gestation (P<0.01). Neonatal baboons, which survived for 5 days (feeding), had a 2.5-fold increase in pancreas weight compared with their counterparts killed at birth (P<0.01). Endocrine cells were also found in exocrine ductal and acinar cells in 125, 140 and 175d GA fetuses. Subpopulation of tissue that coexpressed trypsin and glucagon/insulin shows the presence of cells with mixed endo-exocrine lineage in fetuses. In summary, the fetal endocrine pancreas has no prevalence of a alpha-beta-delta-cell type with larger endocrine cell percent areas than adults. Cells with mixed endocrine/exocrine phenotype occur during fetal development. Developmental differences may play a role in glucose homeostasis during the neonatal period and may have long-term implications. Journal of Endocrinology (2012) 214, 289-299 (literal)

Editore