The role of aromatic side-chains in amyloid growth The role of aromatic side-chains in amyloid growth fragment LANFLVH (Articolo in rivista)

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Label
  • The role of aromatic side-chains in amyloid growth The role of aromatic side-chains in amyloid growth fragment LANFLVH (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.abb.2012.03.022 (literal)
Alternative label
  • Danilo Milardi o Michele F. M. Sciacca o Matteo Pappalardo o Domenico M. Grasso o Carmelo La Rosa (2011)
    The role of aromatic side-chains in amyloid growth The role of aromatic side-chains in amyloid growth fragment LANFLVH
    in European biophysics journal; Springer-Verlag Berlin, Berlin (Germania)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Danilo Milardi o Michele F. M. Sciacca o Matteo Pappalardo o Domenico M. Grasso o Carmelo La Rosa (literal)
Pagina inizio
  • 1 (literal)
Pagina fine
  • 12 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 40 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 12 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • D. Milardi, Istituto di Biostrutture e Bioimmagini, U.O.S. Catania, Consiglio Nazionale delle Ricerche, Viale Andrea Doria 6, 95125 Catania, Italy. M. F. M. Sciacca, M. Pappalardo, D. M. Grasso, C. La Rosa, Dipartimento di Scienze Chimiche, Universita' di Catania, Viale Andrea Doria 6, 95125 Catania, Italy (literal)
Titolo
  • The role of aromatic side-chains in amyloid growth The role of aromatic side-chains in amyloid growth fragment LANFLVH (literal)
Abstract
  • The hydrosoluble resveratrol derivative 3-O-phosphorylresveratrol was shown to be more cytotoxic against DU 145 prostate cancer cells than its analog 4'-O-phosphorylresveratrol. In an attempt to unveil the molecular determinants that lye at the root of their different biological effects, here we investigate the interactions of the two resveratrol derivatives with DMPC model membranes by using DSC, membrane permeation/poration assays and molecular dynamics. The results show that the 3-O-derivative interacts with DMPC membranes and diffuses across them. The 4'-O-derivative lies preferentially onto the surface of membrane. The MD simulations provide a molecular interpretation of the experiments and highlight that, in order to maximize the apolar interactions, the 3-O-derivative is embedded in the lipid hydrophobic region. This topographical position of the 3-O resveratrol analog perturbs the liquid-crystalline order of the lipid bilayer promoting membrane curvature and partial lipid loss from the vesicle. This finding reconciles with the lowering of the enthalpy of the lipid phase transition and the ability of the molecule to diffuse across membranes. The present data contribute to explain the different biological activity of the two molecules and evidence that membrane permeability is a key requirement for effective design of resveratrol derivatives to be used for therapeutic purposes (literal)
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