http://www.cnr.it/ontology/cnr/individuo/prodotto/ID21197
Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets (Articolo in rivista)
- Type
- Label
- Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Cerrato A; De Falco V; Santoro M. (literal)
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Aniello Cerrato, Valentina De Falco and Massimo Santoro
Istituto di Endocrinologia ed Oncologia Sperimentale CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, 'L. Califano',
Universita` Federico II di Napoli, via S. Pansini 5, 80131 Naples, Italy (literal)
- Titolo
- Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets (literal)
- Abstract
- Medullary thyroid carcinoma (MTC) is a rare tumour arising from neural crest-derived parafollicular C-cells. Metastatic
MTC patients are incurable because the cancer does not respond to radiotherapy or chemotherapy. The REarranged
during Transfection (RET) proto-oncogene plays a key role in the development of MTC. However, one-half of the
sporadic MTC do not carry RET mutations. Mice models and early evidence obtained in human samples suggest that
other genes, including those encoding components of the RB1 (retinoblastoma) and TP53 tumour-suppressor pathways,
may be involved in MTC formation. Here, we review the data on the involvement of genes acting in the RET and
RB1/TP53 pathways in MTC. Understanding genetic lesions that occur in MTC is a prerequisite to identifying molecular
therapeutic targets in MTC and in improving the efficacy of RET-targeted therapies. (literal)
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- Autore CNR
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