http://www.cnr.it/ontology/cnr/individuo/prodotto/ID21186
The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation. (Articolo in rivista)
- Type
- Label
- The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation. (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Castellone MD; De Falco V; Rao DM, Bellelli R; Muthu M; Basolo F; Fusco A; Gutkind JS; Santoro M. (literal)
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Castellone MD, Istituto di Endocrinologia ed Oncologia Sperimentale ''G. Salvatore,'' Consiglio Nazionale delle Ricerche, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare ''L. Califano,'' Universita Federico II, Naples, Italy;
De Falco V, Dipartimento di Biologia e Patologia Cellulare e Molecolare ''L. Califano,'' Universita Federico II, Naples, Italy;
Rao DM, Dipartimento di Biologia e Patologia Cellulare e Molecolare ''L. Califano,'' Universita Federico II, Naples, Italy;Department of Genetics, Institute of Basic Molecular Sciences, University of Madras, Madras, India;
Bellelli R, Dipartimento di Biologia e Patologia Cellulare e Molecolare ''L. Califano,'' Universita Federico II, Naples, Italy;
Muthu M, Dipartimento di Biologia e Patologia Cellulare e Molecolare ''L. Califano,'' Universita Federico II, Naples, Italy;
Basolo F, Division of Pathology, Department of Surgery, University of Pisa, Pisa, Italy;
Fusco A, Istituto di Endocrinologia ed Oncologia Sperimentale ''G. Salvatore,'' Consiglio Nazionale delle Ricerche, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare ''L. Califano,'' Universita Federico II, Naples, Italy;
Gutkinf JS, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland
Santoro M, Istituto di Endocrinologia ed Oncologia Sperimentale ''G. Salvatore,'' Consiglio Nazionale delle Ricerche, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare ''L. Califano,'' Universita Federico II, Naples, Italy; (literal)
- Titolo
- The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation. (literal)
- Abstract
- RET/papillary thyroid carcinoma (RET/PTC) oncoproteins
result from the in-frame fusion of the RET receptor tyrosine
kinase domain with protein dimerization motifs encoded by
heterologous genes.Her e, we show that RET/PTC stimulates
the B-catenin pathway.By stimulating PI3K/AKT and Ras/
extracellular signal-regulated kinase (ERK), RET/PTC promotes
glycogen synthase kinase 3B (GSK3B) phosphorylation,
thereby reducing GSK3B-mediated NH2-terminal B-catenin
(Ser33/Ser37/Thr41) phosphorylation.In addition, RET/PTC
physically interacts with B-catenin and increases its phosphotyrosine
content.The increased free pool of S/T(nonphospho)/
Y(phospho)B-catenin is stabilized as a result of the reduced
binding affinity for the Axin/GSK3B complex and activates the
transcription factor T-cell factor/lymphoid enhancer factor.
Moreover, through the ERK pathway, RET/PTC stimulates
cyclic AMP-responsive element binding protein (CREB)
phosphorylation and promotes the formation of a B-catenin-
CREB-CREB-binding protein/p300 transcriptional complex.
Transcriptional complexes containing B-catenin are recruited
to the cyclin D1 promoter and a cyclin D1 gene promoter
reporter is active in RET/PTC-expressing cells.Silencing of
B-catenin by small interfering RNA inhibits proliferation of
RET/PTC-transformed PC Cl3 thyrocytes, whereas a constitutively
active form of B-catenin stimulates autonomous
proliferation of thyroid cells.Thus, multiple signaling events
downstream from RET/PTC converge on B-catenin to stimulate
cell proliferation. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi