GCN5, a yeast transcriptional coactivator, induces chromatin reconfiguration of HIS3 promoter in vivo (Articolo in rivista)

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  • GCN5, a yeast transcriptional coactivator, induces chromatin reconfiguration of HIS3 promoter in vivo (Articolo in rivista) (literal)
Anno
  • 1998-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1006/bbrc.1997.7918 (literal)
Alternative label
  • Filetici P, Aranda C, Gonzàlez A, Ballario P (1998)
    GCN5, a yeast transcriptional coactivator, induces chromatin reconfiguration of HIS3 promoter in vivo
    in Biochemical and biophysical research communications (Print); Elsevier, Oxford (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Filetici P, Aranda C, Gonzàlez A, Ballario P (literal)
Pagina inizio
  • 84 (literal)
Pagina fine
  • 87 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0006291X97979183 (literal)
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  • 242 (literal)
Rivista
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  • 4 (literal)
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  • 1 (literal)
Note
  • PubMed (literal)
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  • Dip. Genetica e Biol.Molecolare, Università La Sapienza, Roma, Dep, Departamento de Genetica Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico (literal)
Titolo
  • GCN5, a yeast transcriptional coactivator, induces chromatin reconfiguration of HIS3 promoter in vivo (literal)
Abstract
  • Gcn5p, the nuclear histone acetyltransferase (HAT A), is a component of the multiprotein adaptor complex, ADA. Its role as a transcriptional coactivator is required for full induction of most of the genes regulated by GCN4. In this study we present experimental evidence demonstrating that, during gene activation, the nuclease sensitive region of HIS3 promoter, harbouring the poly (dA:dT) and the GCN4 binding site, is invaded by nucleosomes in a gcn5 disrupted strain. These data demonstrate, for the first time, that Gcn5p affects directly the chromatin organization of a chromosomal gene during its transcriptional activation. (literal)
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