The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.cellsig.2004.01.002 (literal)

Alternative label

• Mariarosaria Incoronato a; Amelia D'Alessio b; Simona Paladino a; Chiara Zurzolo a; Maria Stella Carlomagno a,c; Laura Cerchia c; Vittorio de Franciscis c (2004)
  The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes.
  in Cellular signalling
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mariarosaria Incoronato a; Amelia D'Alessio b; Simona Paladino a; Chiara Zurzolo a; Maria Stella Carlomagno a,c; Laura Cerchia c; Vittorio de Franciscis c (literal)

Pagina inizio

• 847 (literal)

Pagina fine

• 856 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 16 (literal)

Rivista

• Cellular signalling (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 7 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita` di Napoli ''Federico II'', Via S. Pansini 5, 80131, Naples, Italy b Oncologia Sperimentale E, Istituto Nazionale Tumori, Fondazione ''G. Pascale'', Via M. Semmola, 80131, Naples, Italy c Istituto di Endocrinologia ed Oncologia Sperimentale del CNR ''G. Salvatore'', via S. Pansini 5, 80131, Naples, Italy (literal)

Titolo

• The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes. (literal)

Abstract

• The Shp-2 and Shp-1 non-transmembrane tyrosine phosphatases display different and even opposing effects on downstream signaling events initiated by Ret activation. By using rat pheochromocytoma-derived PC 12 cells, here we studied the interactions of Shp-2 and Shp-1 with two activated mutants of Ret receptor, Ret(C634Y) and Ret(M918T). Each of these mutated receptors causes inheritance of distinct cancer syndromes, multiple endocrine neoplasia (MEN) type 2A and type 2B, respectively. We show that: (i) both Shp-1 and Shp-2 are associated to a multiprotein complex that includes Ret mutants; (ii) the Shp-1-Ret complexes are distinct from Shp-2-Ret complexes, and these complexes are differently distributed inside and outside lipid rafts; (iii) constitutively activated Ret proteins neither directly bind to nor are substrates of these phosphatases. Our results well support the evidence that Ret complexes within and outside rafts mediate distinct biological functions, and indicate that the presence of either Slips participates to determine such functions. (literal)

Prodotto di

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Strategie innovative per la terapia e la diagnosi dei tumori (SV.P15.001.005) (Modulo)

Autore CNR

• VITTORIO DE FRANCISCIS (Persona)
• LAURA CERCHIA (Persona)

Insieme di parole chiave

• Keywords of "The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• LAURA CERCHIA (Persona)
• VITTORIO DE FRANCISCIS (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Strategie innovative per la terapia e la diagnosi dei tumori (SV.P15.001.005) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cellular signalling (Rivista)

Insieme di parole chiave di

• Keywords of "The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes." (Insieme di parole chiave)