The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S1097-2765(04)00153-4 (literal)

Alternative label

• Marinissen MJ, Chiariello M, Tanos T, Bernard O, Narumiya S, Gutkind JS. (2004)
  The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis.
  in Molecular cell
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Marinissen MJ, Chiariello M, Tanos T, Bernard O, Narumiya S, Gutkind JS. (literal)

Pagina inizio

• 29 (literal)

Pagina fine

• 41 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 14 (literal)

Rivista

• Molecular cell (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• National Institute of Dental and Craniofacial Research National Institutes of Health Bethesda, MD Facultad de Ciencias Exactas, Universidad de Buenos Aires Buenos Aires Argentina Istituto di Endocrinologia ed Oncologia Sperimentale, CNR Napoli Italy The Walter and Eliza Hall Institute of Medical Research Parkville Victoria Australia Department of Pharmacology Kyoto University Faculty of Medicine Sakyo-ku, Kyoto Japan (literal)

Titolo

• The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. (literal)

Abstract

• RhoA regulates the actin cytoskeleton and the expres- sion of genes associated with cell proliferation. This includes c-fos and c-jun, which are members of the AP1 family of transcription factors that play a key role in normal and aberrant cell growth. Whereas RhoA stimulates the c-fos SRE by a recently elucidated mechanism that is dependent on actin treadmilling, how RhoA regulates c-jun is still poorly understood. We found that RhoA stimulates c-jun expression through ROCK, but independently from the ability of ROCK to promote actin polymerization. Instead, we found that ROCK activates JNK, which then phosphor- ylates c-Jun and ATF2 when bound to the c-jun pro- moter. Thus, ROCK represents a point of signal diver- gence downstream from RhoA, as it promotes actin reorganization and the consequent expression from the c-fos SRE, while a parallel pathway connects ROCK to JNK, thereby stimulating c-jun expression. Ultimately, these pathways converge in the nucleus to regulate AP1 activity. (literal)

Prodotto di

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Identificazione e caratterizzazione funzionale dei geni e delle proteine coinvolti nella tumorigenesi tiroidea (SV.P15.001.004) (Modulo)

Autore CNR

• MARIO CHIARIELLO (Persona)

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• Parole chiave di "The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis." (Insieme di parole chiave)

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Autore CNR di

• MARIO CHIARIELLO (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Identificazione e caratterizzazione funzionale dei geni e delle proteine coinvolti nella tumorigenesi tiroidea (SV.P15.001.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular cell (Rivista)

Insieme di parole chiave di

• Parole chiave di "The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis." (Insieme di parole chiave)