http://www.cnr.it/ontology/cnr/individuo/prodotto/ID21128
Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. (Articolo in rivista)
- Type
- Label
- Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. (Articolo in rivista) (literal)
- Anno
- 2004-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Castellone MD; Guarino V; De Falco V; Carlomagno F; Basolo F; Faviana P; Kruhoffer M; Orntoft T; Russell JP; Rothstein JL; Fusco A; Santoro M; Melillo RM. (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Castellone MD; Guarino V; De Falco V; Carlomagno F, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR 'G Salvatore', c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, 80131 Naples, Italy;
Basolo F; Faviana P, Dipartimento di oncologia, Pisa, Italy;
Kruhoffer M; Orntoft T, Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Aarhus, Denmark;
Russell JP; Rothstein JL, Departments of Microbiology/Immunology and Otolaryngology-Head and neck surgery, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA;
Fusco A; Santoro M; Melillo RM,Istituto di Endocrinologia ed Oncologia Sperimentale del CNR 'G Salvatore', c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, 80131 Naples, Italy; (literal)
- Titolo
- Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. (literal)
- Abstract
- To identify genes involved in the transformation of thyroid
follicular cells, we explored, using DNA oligonucleotide
microarrays, the transcriptional response of PC Cl3 rat
thyroid epithelial cells to the ectopic expression of the
RET/PTC oncogenes. We found that RET/PTC was able
to induce the expression of CXCR4, the receptor for the
chemokine CXCL12/SDF-1a/b. We observed that
CXCR4 expression correlated with the transforming
ability of the oncoprotein and depended on the integrity
of the RET/PTC-RAS/ERK signaling pathway. We
found that CXCR4 was expressed in RET/PTC-positive
human thyroid cancer cell lines, but not in normal thyroid
cells. Furthermore, we found CXCR4 expression in human
thyroid carcinomas, but not in normal thyroid samples by
immunohistochemistry. Since CXCR4 has been recently
implicated in tumor proliferation, motility and invasiveness,
we asked whether treatment with SDF-1a was able
to induce a biological response in thyroid cells. We
observed that SDF-1a induced S-phase entry and survival
of thyroid cells. Invasion through a reconstituted extracellular
matrix was also supported by SDF-1a and
inhibited by a blocking antibody to CXCR4. Taken
together, these results suggest that human thyroid cancers
bearing RET/PTC rearrangements may use the CXCR4/
SDF-1a receptor-ligand pathway to proliferate, survive
and migrate. (literal)
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