http://www.cnr.it/ontology/cnr/individuo/prodotto/ID21116
Overexpression of chromatin assembly factor-1 (CAF-1) p60 is predictive of adverse behaviour of prostatic cancer (Articolo in rivista)
- Type
- Label
- Overexpression of chromatin assembly factor-1 (CAF-1) p60 is predictive of adverse behaviour of prostatic cancer (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1111/j.1365-2559.2009.03266.x (literal)
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- Staibano S;Mascolo M; Mancini FP; Kisslinger A; Salvatore G; Di Benedetto M; Chieffi P;Altieri V; Prezioso D; Ilardi G;De Rosa G;Tramontano D. (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Department of Biomorphological and Functional Sciences, Pathology Section, University of Naples \"Federico II\", Naples
Department of Biological and Environmental Sciences, University of Sannio, Benevento
IEOS,CNR, Naples,Italy
Department of Medicine, University of Naples \"Federico II\", Naples
Department of Experimental Medicine, Second University of Naples, Naples
Department of Urology, University of Naples \"Federico II\", Naples, Italy
I.R.C.C.S., Rionero in Vulture, Potenza, Italy (literal)
- Titolo
- Overexpression of chromatin assembly factor-1 (CAF-1) p60 is predictive of adverse behaviour of prostatic cancer (literal)
- Abstract
- Aims: Prostatic cancer may remain organ-confined indefinitely; in a number of patients, however it gives rise to clinical symptoms and death. The biological behaviour of this tumour mostly remains difficult to predict. A promising tool for diagnosis and prognosis of some human tumours is the chromatin assembly factor-1 (CAF-1), involved in the control of higher order chromatin organization. The aim was to explore the role of CAF-1/p60 protein as a new prognostic marker for prostatic cancer. Methods and results: The expression of CAF-1/p60 was evaluated by immunohistochemistry and Western blotting in a selected series of prostatic cancers and in prostatic cancer cell lines. Results were compared with
clinicopathological data and outcome of patients. CAF-1/p60 was expressed in all cases, with a linear increase from low-grade tumours (Gleason score <7) to high-grade prostatic cancers (Gleason score >7). By com-paring results with follow-up data, a significant association between overexpression of CAF-1/p60 and unfavourable behaviour of prostatic cancer emerged, and its predictive value was independent of classical
prognostic factors. Conclusions: In our series of cases, overexpression of CAF-1/p60 characterized prostatic cancers with a worse prognosis. CAF-1/p60 has a potential role as a new reliable prognostic biomarker for prostatic cancer. (literal)
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