http://www.cnr.it/ontology/cnr/individuo/prodotto/ID211155
Urinary desmosine excretion is inversely correlated with the extent of emphysema in patients with chronic obstructive pulmonary disease (Articolo in rivista)
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- Urinary desmosine excretion is inversely correlated with the extent of emphysema in patients with chronic obstructive pulmonary disease (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
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Franca Cocci (a,b), Massimo Miniati (a), Simonetta Monti (a), Eleonora Cavarra (d), Federica Gambelli (d), Luigi Battolla (c), Monica Lucattelli (d), Giuseppe Lungarella (d) (2002)
Urinary desmosine excretion is inversely correlated with the extent of emphysema in patients with chronic obstructive pulmonary disease
in International journal of biochemistry & cell biology; pergamon, exeter (Regno Unito)
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- Franca Cocci (a,b), Massimo Miniati (a), Simonetta Monti (a), Eleonora Cavarra (d), Federica Gambelli (d), Luigi Battolla (c), Monica Lucattelli (d), Giuseppe Lungarella (d) (literal)
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- a Istituto di Fisiologia Clinica del Consiglio Nazionale delle Ricerche (CNR), Area di Ricerca San Cataldo, Via Moruzzi 1, 56126 Pisa, Italy
b Dipartimento di Cardiologia, Angiologia e Pneumologia, Università di Pisa, Pisa, Italy
c Istituto di Radiologia, Università di Pisa, Pisa, Italy
d Dipartimento di Fisiopatologia e Medicina Sperimentale, Università di Siena, Siena, Italy (literal)
- Titolo
- Urinary desmosine excretion is inversely correlated with the extent of emphysema in patients with chronic obstructive pulmonary disease (literal)
- Abstract
- An enhanced proteolysis of lung interstitium is key event in the pathogenesis of emphysema, a major constituent of chronic
obstructive pulmonary disease. To assess whether urinary desmosine and/or hydroxyproline may be used as a marker of lung
destruction we studied urinary excretions of these products in 20 patients with chronic obstructive pulmonary disease and in 19
appropriate controls in 24 h urine collection samples. For desmosine measurements, we developed a new indirect competitive
enzyme-linked immunosorbent assay. The extent of emphysema was measured in high resolution computed tomography (CT)
scans, by considering lung area with CT numbers <-950 Hounsfield units (HU).
Urinary desmosine excretionwas significantly higher in patients with chronic obstructive pulmonary disease than in controls
(294 ± 121?g versus 183 ± 93?g, P = 0.003), and was unrelated with both age and smoking habits. In patients with no
evidence or only mild emphysema, desmosine excretion values were significantly higher (P = 0.006) than those of patients
with moderate to severe emphysema. In patients with chronic obstructive pulmonary disease, urinary hydroxyproline excretion
was positively correlated with urinary desmosine excretion but on the average, it was not different from that of controls.
These data indicate that urinary desmosine is a sensitive biological marker of lung elastin catabolism. The relatively low
levels of urinary desmosine observed in patients with severe emphysemamay be accounted for a decrease in elastin catabolism
due to reduced lung elastin mass. Urinary desmosine may be used to identify subjects at risk of developing emphysema and
to assess the efficacy of therapeutic interventions. (literal)
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