Antioxidant-rich food supplement Lisosan G induces reversion of hepatic steatosis (Articolo in rivista)

Type
Label
  • Antioxidant-rich food supplement Lisosan G induces reversion of hepatic steatosis (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Alternative label
  • M.N. Laus, F. Denoth, M. Ciardi, L. Giorgetti, L. Pucci, R. Sacco, D. Pastore, V. Longo (2013)
    Antioxidant-rich food supplement Lisosan G induces reversion of hepatic steatosis
    in Medycyna Weterynaryjna
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • M.N. Laus, F. Denoth, M. Ciardi, L. Giorgetti, L. Pucci, R. Sacco, D. Pastore, V. Longo (literal)
Pagina inizio
  • 235 (literal)
Pagina fine
  • 240 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 69 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 4 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dip Scienze agrarie, degli alimenti e dell'ambiente, Università di Foggia; Istituto di Fisiologia Clinica, CNR Pisa; Istituto di Biologia e Biotecnologia Agraria CNR, Pisa; U.O. Gastroenterologia e Malattie del Ricambio, AOUP, Pisa. (literal)
Titolo
  • Antioxidant-rich food supplement Lisosan G induces reversion of hepatic steatosis (literal)
Abstract
  • Antioxidant activity (AA) of Lisosan G, a food supplement obtained from wheat grains, was evaluated by using the LOX/RNO, ORAC and TEAC methods. Very high AA was found, associated with a high fraction of freely-extractable phytochemicals expected to be readily absorbed in the small intestine and to exert systemic healthy effects. So, a possible beneficial effect of Lisosan G against non-alcoholic hepatic steatosis induced in mice by 90 days of hyperlipidic diet was studied. Feeding Lisosan G to mice with hepatic steatosis caused rapid reversion of liver disorder: just after 7 days the liver resulted free of steatosis, showing triglyceride content and histological properties similar to control group. Contrarily, the switch of hyperlipidic diet towards a standard diet did not rapidly reverse hepatic steatosis, with a recovery observed only after 30 days. Our results shed a first insight on the therapeutic potential of Lisosan G against the hepatic steatosis disorder in animal species. (literal)
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