In vitro activity of the alfavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• In vitro activity of the alfavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells. (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Alternative label

• Pisano M, de Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C (2013)
  In vitro activity of the alfavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells.
  in Anticancer research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Pisano M, de Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C (literal)

Pagina inizio

• 871 (literal)

Pagina fine

• 879 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 33 (literal)

Rivista

• Anticancer research (Rivista)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• ICB sede di Sassari (literal)

Titolo

• In vitro activity of the alfavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells. (literal)

Abstract

• Background: In malignant melanoma (MM), overexpression of alfavbeta3 integrin is linked to a more metastatic phenotype. Development of anti-alfavbeta3 agents able to counteract melanoma progression would be helpful for disease treatment. A new selective ligand of alfavbeta3, RGDechi-hCit, has anti-angiogenic properties against endothelial cells in angiogenesis animal models. Aim of this study was to evaluate the in vitro effects of the RGDechi-hCit peptide on MM cell lines. Material and Methods: Cytofluorimetric analysis characterized cell surface expression of alfavbeta3 integrin on seven MM cell lines. Cell proliferation, adhesion, and migration assays were carried out using the alfavbeta3-antagonist RGDechi-hCit. Results: Proliferation was not significantly inhibited by RGDechi-hCit, though striking morphological changes were detected in MM cell lines highly expressing alfavbeta3. Conversely, assays on fibronectin-coated plates showed a significant RGDechi-hCit dose-dependent inhibitory effect on both adhesion and migration. Conclusions: Data demonstrate anti-adhesion and anti-migration, but not anti-proliferative, activities of RGDechi-hCit against MM cells. (literal)

Prodotto di

• Studio biologico cellulare di molecole bioattive nei tumori (PM.P06.017.003) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)
• Institute of Crystallography (IC) (Istituto)
• Istituto di chimica biomolecolare (ICB) (Istituto)
• Biomarcatori e bioterapie nei tumori umani (PM.P06.017.002) (Modulo)
• Molecular Design (Dipartimento)

Autore CNR

• Ilaria Sassu (Persona)
• GIUSEPPE PALMIERI (Persona)
• MICHELE SAVIANO (Persona)
• LAURA ZACCARO (Persona)
• MARINA PISANO (Unità di personale interno)
• CARLA MARIA ROZZO (Unità di personale interno)
• ANNARITA DEL GATTO (Persona)
• Sara Cossu (Unità di personale esterno)

Incoming links:

Prodotto

• Molecular Design (Dipartimento)
• Institute of Crystallography (IC) (Istituto)
• Institute of biostructure and bioimaging (IBB) (Istituto)
• Istituto di chimica biomolecolare (ICB) (Istituto)
• Biomarcatori e bioterapie nei tumori umani (PM.P06.017.002) (Modulo)
• Studio biologico cellulare di molecole bioattive nei tumori (PM.P06.017.003) (Modulo)

Autore CNR di

• MICHELE SAVIANO (Persona)
• MARINA PISANO (Unità di personale interno)
• GIUSEPPE PALMIERI (Persona)
• CARLA MARIA ROZZO (Unità di personale interno)
• LAURA ZACCARO (Persona)
• Sara Cossu (Unità di personale esterno)
• Ilaria Sassu (Persona)
• ANNARITA DEL GATTO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Anticancer research (Rivista)