http://www.cnr.it/ontology/cnr/individuo/prodotto/ID210633

Glycomics of pediatric and adulthood diseases of the central nervous system (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Glycomics of pediatric and adulthood diseases of the central nervous system (Articolo in rivista) (literal)

Anno

2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1016/j.jprot.2012.07.007 (literal)

Alternative label

R.Barone , L.Sturiale, A.Palmigiano, M. Zappia, D.Garozzo (2012)
Glycomics of pediatric and adulthood diseases of the central nervous system
in Journal of proteomics (Print); Elsevier, Amsterdam (Paesi Bassi)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

R.Barone , L.Sturiale, A.Palmigiano, M. Zappia, D.Garozzo (literal)

Pagina inizio

5123 (literal)

Pagina fine

5139 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.sciencedirect.com/science/article/pii/S1874391912005374 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

75 (literal)

Rivista

Journal of proteomics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

17 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

17 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

a Pediatric Neurology Unit, Dept. of Pediatrics, University of Catania, Via S. Sofia 78, 95125 Catania, Italy b Institute of Chemistry and Technology of Polymers, CNR, Via P. Gaifami 18, 95126 Catania, Italy c Section of Neurosciences, Dept. GF Ingrassia, University of Catania, Via S. Sofia 78, 95125 Catania, Italy (literal)

Titolo

Glycomics of pediatric and adulthood diseases of the central nervous system (literal)

Abstract

Glycosylation consists in the covalent linkage of a carbohydrate structure to membrane bound and secreted glycoconjugates. It is a common post-translational modification that serves multiple functions in cell differentiation, signaling and intercellular communication. Unlike DNA/RNA/protein, the addition of complex carbohydrates is not-template driven and it is conceivable that both genetics and environmental factors might interact to influence glycosylation machinery in several pathological processes. Over the last few decades, the recognition of Congenital Disorders of Glycosylation (CDG) as an increasing number of genetic diseases of glycosylation with almost constant nervous system involvement, dramatically illustrated the consequences of abnormal glycosylation as improper CNS development and function. In addition, CDG recognition contributed to postulate that aberrant glycosylation processes might play a role in multifactorial, complex CNS diseases. On this context, CNS glycomics explores the effects of possible aberrant glycosylation to identify potential glyco-biomarkers useful for the diagnosis and ultimately for potential intervention strategies in neurological diseases. Up to date, CNS glycomics is an emerging, still uncharted area because of the specificity of CNS glycosylation, the complexity of the neurological disorders and for the inaccessibility and invasiveness of disease relevant samples. Here we review current knowledge on clinical glycomics of nervous system diseases, starting with CDG to include those pediatric and adulthood neuropsychiatric diseases where some evidences suggest that multifactor determinants converge to dysregulate glycosylation. Conventional and mass spectrometry-based high throughput technology for glyco-biomarker detection in CNS diseases is reported. (literal)

Editore