http://www.cnr.it/ontology/cnr/individuo/prodotto/ID21042
A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma. (Articolo in rivista)
- Type
- Label
- A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma. (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1158/0008-5472.CAN-07-1887 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Salvatore G; Nappi TC; Salerno P; Jiang Y; Garbi C; Ugolini C; Miccoli P; Basolo F; Castellone MD; Cirafici AM; Melillo RM; Fusco A; Bittner ML; Santoro M. (literal)
- Pagina inizio
- Pagina fine
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- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Castellone M.D. Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare ''L. Califano'' , Universita' ''Federico II'', Naples, Italy
Cirafici AM, Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare ''L. Califano'' , Universita' ''Federico II'', Naples, Italy
Melillo R.M. Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare ''L. Califano'' , Universita' ''Federico II'', Naples, Italy
Fusco A. Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare ''L. Califano'' , Universita' ''Federico II'', Naples, Italy
Santoro M. Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare ''L. Califano'' , Universita' ''Federico II'', Naples, Italy (literal)
- Titolo
- A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma. (literal)
- Abstract
- Here, we show that the anaplastic thyroid carcinoma (ATC)
features the up-regulation of a set of genes involved in the
control of cell cycle progression and chromosome segregation.
This phenotype differentiates ATC from normal tissue and
from well-differentiated papillary thyroid carcinoma. Transcriptional
promoters of the ATC up-regulated genes are
characterized by a modular organization featuring binding
sites for E2F and NF-Y transcription factors and cell cycle-
dependent element (CDE)/cell cycle gene homology region
(CHR) cis-regulatory elements. Two protein kinases involved in
cell cycle regulation, namely, Polo-like kinase 1 (PLK1) and T
cell tyrosine kinase (TTK), are part of the gene set that is
up-regulated in ATC. Adoptive overexpression of p53, p21
(CIP1/WAF1), and E2F4 down-regulated transcription from the
PLK1 and TTK promoters in ATC cells, suggesting that these
genes might be under the negative control of tumor suppressors
of the p53 and pRB families. ATC, but not normal thyroid,
cells depended on PLK1 for survival. RNAi-mediated PLK1
knockdown caused cell cycle arrest associated with 4N DNA
content and massive mitotic cell death. Thus, thyroid cell
anaplastic transformation is accompanied by the overexpression
of a cell proliferation/genetic instability-related gene
cluster that includes PLK1 kinase, which is a potential molecular
target for ATC treatment. (literal)
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