UbcH10 is overexpressed in malignant breast carcinomas. (Articolo in rivista)

Type
Label
  • UbcH10 is overexpressed in malignant breast carcinomas. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ejca.2007.09.003 (literal)
Alternative label
  • Maria Teresa Berlingieri a, Pierlorenzo Pallante a,d, Andrea Sboner b, Mattia Barbareschi c, Mimma Bianco a,d, Angelo Ferraro d, Gelsomina Mansueto d, Eleonora Borbone d, Eliana Guerriero d,e, Giancarlo Troncone d,e, Alfredo Fusco a,d (2007)
    UbcH10 is overexpressed in malignant breast carcinomas.
    in European journal of cancer (1990)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Maria Teresa Berlingieri a, Pierlorenzo Pallante a,d, Andrea Sboner b, Mattia Barbareschi c, Mimma Bianco a,d, Angelo Ferraro d, Gelsomina Mansueto d, Eleonora Borbone d, Eliana Guerriero d,e, Giancarlo Troncone d,e, Alfredo Fusco a,d (literal)
Pagina inizio
  • 2729 (literal)
Pagina fine
  • 2735 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • https://www.ejconline.com (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 43 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta` di Medicina e Chirurgia di Napoli, Universita` degli Studi di Napoli ''Federico II'', via S.Pansini 5, 80131 Naples, Italy b Bioinformatics - SRA Division ITC-irst, Centre for Scientific and Technological Research, 38050 Povo (Trento), Italy c U.O. Anatomia Patologica Ospedale S. Chiara Largo Medaglie d'Oro 38100 Trento, Italy d NOGEC (Naples Oncogenomic Center)-CEINGE, Biotecnologie Avanzate-Napoli, & SEMM - European School of Molecular Medicine - Naples Site, via Comunale Margherita, 482, 80145, Naples, Italy e Dipartimento di Anatomia Patologica e Citopatologia, Facolta` di Medicina e Chirurgia, Universita` di Napoli ''Federico II'', via S.Pansini 5, 80131 Naples, Italy (literal)
Titolo
  • UbcH10 is overexpressed in malignant breast carcinomas. (literal)
Abstract
  • Our group has recently demonstrated the overexpression of the UbcH10 gene in undifferentiated thyroid carcinomas. Subsequently, a clear correlation between UbcH10 overexpression and a reduced survival in ovarian carcinoma patients has been described indicating UbcH10 as a valid prognostic marker in this neoplastic disease. Here we have extended the analysis of the UbcH10 expression to neoplastic breast diseases. We demonstrated, by tissue micro-arrays immunohistochemical studies, a significant difference (p=0.0001) in the mean percentage of UbcH10 stained cells between benign (0.22%) and malignant (11.01%) neoplastic lesions. High UbcH10 expression was associated with intense Ki-67 staining (p=0.015) and ErbB2 positivity (p=0.092). The suppression of the ErbB2 expression in breast carcinoma cell lines induces a reduction of UbcH10 level. Consistently, the inhibition of breast carcinoma cell growth was achieved following the block of UbcH10 protein synthesis by RNA interference. Therefore, these results suggest the perspective of a therapy of aggressive breast carcinomas based on the suppression of the UbcH10 function. (literal)
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