The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 protein forms an SCF ubiquitin ligase and regulates hypocotyl elongation. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 protein forms an SCF ubiquitin ligase and regulates hypocotyl elongation. (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Alternative label

• Franciosini A.a, Lombardi B.a, Iafrate S.b, Pecce V.a, Mele G.b, Lupacchini L., Kondou Y.c, Gusmaroli G.f, Aki S.e, Tsuge T.e, Deng X.-W.f, Matsui M.c, Costantino P.a, Serino G.a,g, (2013)
  The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 protein forms an SCF ubiquitin ligase and regulates hypocotyl elongation.
  in Molecular Plant (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Franciosini A.a, Lombardi B.a, Iafrate S.b, Pecce V.a, Mele G.b, Lupacchini L., Kondou Y.c, Gusmaroli G.f, Aki S.e, Tsuge T.e, Deng X.-W.f, Matsui M.c, Costantino P.a, Serino G.a,g, (literal)

Rivista

• Molecular Plant (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, Italy b Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche, Italy c RIKEN Plant Science Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan d Institute for Biology, Applied Genetics, Dahlem Centre of Plant Science (DCPS), Free University, Berlin, Germany e Molecular Biology Laboratory, ICR, Kyoto University, Japan f Department of Molecular, Cellular, and Development Biology, Yale University, New Haven, CT, USA g The New York Botanical Garden, Bronx, NY, USA (literal)

Titolo

• The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 protein forms an SCF ubiquitin ligase and regulates hypocotyl elongation. (literal)

Abstract

• The regulation of protein turnover by the ubiquitin proteasome system (UPS) is a major post-translational mechanism in eukaryotes. One of the key components of the UPS, the COP9 signalosome (CSN), regulates \"cullin-ring\" E3 ubiquitin ligases. In plants, CSN participates in diverse cellular and developmental processes, ranging from light signaling to cell cycle control. In this work, we isolated a new plant-specific CSN-interacting F-box protein, which we denominated CFK1 (COP9 INTERACTING F-BOX KELCH 1). We show that in Arabidopsis thaliana CFK1 is a component of a functional ubiquitin ligase complex. We also show that CFK1 stability is regulated by CSN and by proteasome-dependent proteolysis, and that light induces accumulation of the CFK1 transcript in the hypocotyl. Analysis of CFK1 knockdown, mutant and overexpressing seedlings indicates that CFK1 promotes hypocotyl elongation by increasing cell size. Reduction of CSN levels enhances the short hypocotyl phenotype of CFK1 depleted seedlings, while complete loss of CSN activity suppresses the long hypocotyl phenotype of CFK1 overexpressing seedlings. We propose that CFK1 (and its regulation by CSN) is a novel component of the cellular mechanisms controlling hypocotyl elongation. (literal)

Prodotto di

• Institute of agricultural biology and biotechnology (IBBA) (Istituto)
• Basi Genetiche, Fisiologiche e Molecolari dello Sviluppo e Differenziamento di Specie Modello e di Interesse Agro-Alimentare in Risposta a Fattori Endogeni e Ambientali (AG.P01.003.001) (Modulo)

Autore CNR

• GIOVANNI MELE (Persona)

Incoming links:

Prodotto

• Institute of agricultural biology and biotechnology (IBBA) (Istituto)
• Basi Genetiche, Fisiologiche e Molecolari dello Sviluppo e Differenziamento di Specie Modello e di Interesse Agro-Alimentare in Risposta a Fattori Endogeni e Ambientali (AG.P01.003.001) (Modulo)

Autore CNR di

• GIOVANNI MELE (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular Plant (Rivista)