Activation of the Erk8 MAP kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Activation of the Erk8 MAP kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1074/jbc.M513397200 (literal)

Alternative label

• Iavarone C., Acunzo M., Carlomagno F., Catania A., Melillo R.M., Carlomagno M.S., Santoro M. and Chiariello M. (2006)
  Activation of the Erk8 MAP kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene
  in Journal of biological chemistry (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Iavarone C., Acunzo M., Carlomagno F., Catania A., Melillo R.M., Carlomagno M.S., Santoro M. and Chiariello M. (literal)

Pagina inizio

• 10567 (literal)

Pagina fine

• 10576 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.jbc.org/content/281/15/10567.long (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 281 (literal)

Rivista

• Journal of biological chemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università degli Studi di Napoli Istituto di Endocrinologia e Oncologia Sperimentale, CNR, Italy (literal)

Titolo

• Activation of the Erk8 MAP kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene (literal)

Abstract

• Mitogen-activated protein (MAP) kinases have a central role in several biological functions, including cell adhesion and spreading, chemotaxis, cell cycle progression, differentiation, and apoptosis. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. Here, we show that RET/PTC3, an activated form of the RET proto-oncogene, was able to activate Erk8, and we demon- strate that such MAP kinase participated in RET/PTC3-dependent stimulation of the c-jun promoter. By using RET/PTC3 molecules mutated in specific tyrosine autophosphorylation sites, we charac- terized Tyr981, a known binding site for c-Src, as a major determi- nant of RET/PTC3-induced Erk8 activation, although, surprisingly, the underlying mechanism did not strictly depend on the activity of Src. In contrast, we present evidence that RET/PTC3 acts on Erk8 through Tyr981-mediated activation of c-Abl. Furthermore, we localized the region responsible for the modulation of Erk8 activity by the RET/PTC3 and Abl oncogenes in the Erk8 C-terminal domain. Altogether, these results support a role for Erk8 as a novel effector of RET/PTC3 and, therefore, RET biological functions. (literal)

Prodotto di

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Individuazione di bersagli molecolari per lo sviluppo di terapie per i tumori (SV.P15.012.001) (Modulo)
• Espressione genica e cancerogenesi tiroidea (SV.P15.001.001) (Modulo)
• Meccanismi di controllo della trasmissione dei segnali intracellulari (SV.P15.013.001) (Modulo)

Autore CNR

• ROSA MARINA MELILLO (Persona)
• MARIO CHIARIELLO (Persona)

Incoming links:

Autore CNR di

• ROSA MARINA MELILLO (Persona)
• MARIO CHIARIELLO (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Espressione genica e cancerogenesi tiroidea (SV.P15.001.001) (Modulo)
• Individuazione di bersagli molecolari per lo sviluppo di terapie per i tumori (SV.P15.012.001) (Modulo)
• Meccanismi di controllo della trasmissione dei segnali intracellulari (SV.P15.013.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of biological chemistry (Rivista)