A family of rapidly evolving genes from the sex reversal critical region in Xp21. (Articolo in rivista)

Type
Label
  • A family of rapidly evolving genes from the sex reversal critical region in Xp21. (Articolo in rivista) (literal)
Anno
  • 1995-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/BF00352360 (literal)
Alternative label
  • Dabovic B, Zanaria E, Bardoni B, Lisa A, Bordignon C, Russo V, Matessi C, Traversari C, Camerino G. (1995)
    A family of rapidly evolving genes from the sex reversal critical region in Xp21.
    in Mammalian genome (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Dabovic B, Zanaria E, Bardoni B, Lisa A, Bordignon C, Russo V, Matessi C, Traversari C, Camerino G. (literal)
Pagina inizio
  • 571 (literal)
Pagina fine
  • 580 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://link.springer.com/article/10.1007/BF00352360 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 6 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 9 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Biologia Generale e Genetica Medica, Universita \" di Pavia, via Forlanini 14, 27100 Pavia, Italy; Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, 27100 Pavia, Italy; Gene therapy program, DIBIT, Ist. Scientifico H.S. Raffaele, via Olgettina, 58, 45100 Milano, Italy; Istituto di Istologia ed Embriologia, Universita \" di Sassari, via S. Pietro 43/13, Sassari, Italy. (literal)
Titolo
  • A family of rapidly evolving genes from the sex reversal critical region in Xp21. (literal)
Abstract
  • Patients with an intact SRY gene and duplications of portions of Xp21 develop as phenotypic females. We have recently mapped this sex reversal locus, DSS, to a 160-kb region of Xp21 that includes the adrenal hypoplasia congenita locus. To clone the gene(s) underlying DSS and AHC, we isolated expressed sequences from the region. Here we describe the characterization of two related genes. DAM10 and DAM6, expressed in adult testis and lung tumors. The predicted DAM10 and DAM6 proteins are 66% identical and are both highly similar to the MAGE family of tumor-associated antigens and to mouse necdin. Genes belonging to the MAGE superfamily, DAMs, MAGEs, and necdin, are likely to have originated from a common ancestor and to be subject to an unusually rapid evolution. The tumor-restricted expression of DAM proteins and their structural similarity to MAGE genes suggest that DAM peptides may be targets for active immunotherapy in lung cancer patients. (literal)
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