Pyrazinoporphyrazines with Externally Appended Pyridine Rings. 13. Structure, UV-Visible Spectral Features, and Noncovalent Interaction with DNA of a Positively Charged Binuclear (Zn-II/Pt-II) Macrocycle with Multimodal Anticancer Potentialities (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Pyrazinoporphyrazines with Externally Appended Pyridine Rings. 13. Structure, UV-Visible Spectral Features, and Noncovalent Interaction with DNA of a Positively Charged Binuclear (Zn-II/Pt-II) Macrocycle with Multimodal Anticancer Potentialities (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/ic3020755 (literal)

Alternative label

• Manet, Ilse [ 1 ] ; Manoli, Francesco [ 1 ] ; Donzello, Maria Pia [ 2 ] ; Viola, Elisa [ 2 ] ; Masi, Annalisa [ 3 ] ; Andreano, Giuseppina [ 3 ] ; Ricciardi, Giampaolo [ 4 ] ; Rosa, Angela [ 4 ] ; Cellai, Luciano [ 3 ] ; Ercolani, Claudio [ 2 ] ; Monti, Sandra [ 1 ] (2013)
  Pyrazinoporphyrazines with Externally Appended Pyridine Rings. 13. Structure, UV-Visible Spectral Features, and Noncovalent Interaction with DNA of a Positively Charged Binuclear (Zn-II/Pt-II) Macrocycle with Multimodal Anticancer Potentialities
  in Inorganic chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Manet, Ilse [ 1 ] ; Manoli, Francesco [ 1 ] ; Donzello, Maria Pia [ 2 ] ; Viola, Elisa [ 2 ] ; Masi, Annalisa [ 3 ] ; Andreano, Giuseppina [ 3 ] ; Ricciardi, Giampaolo [ 4 ] ; Rosa, Angela [ 4 ] ; Cellai, Luciano [ 3 ] ; Ercolani, Claudio [ 2 ] ; Monti, Sandra [ 1 ] (literal)

Pagina inizio

• 321 (literal)

Pagina fine

• 328 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 52 (literal)

Rivista

• Inorganic chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• [ 1 ] CNR, Ist Sintesi Organ & Fotoreatt, I-40129 Bologna, Italy [ 2 ] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy [ 3 ] CNR, Ist Cristallog, Area Ric Roma 1, I-00015 Rome, Italy [ 4 ] Univ Basilicata, Dipartimento Sci, I-85100 Potenza, Italy (literal)

Titolo

• Pyrazinoporphyrazines with Externally Appended Pyridine Rings. 13. Structure, UV-Visible Spectral Features, and Noncovalent Interaction with DNA of a Positively Charged Binuclear (Zn-II/Pt-II) Macrocycle with Multimodal Anticancer Potentialities (literal)

Abstract

• We investigated with spectroscopic techniques the noncovalent interaction of a bimetallic water-soluble (Zn-II/Pt-II) porphyrazine hexacation, [(PtCl2)(CH3)(6)LZn](6+), and its octacationic analogue [(CH3)(8)LZn](8+), lacking the cis-platin-like functionality, with a 21-mer double strand (ds) 5'-d[GGG(TTAGGG)(3)]-3'/3'-d[CCC(AATCCC)(3)]-5', as model for B-DNA. Both hexacation and octacation tend to aggregate in water. The structure as well as the ground and excited-state electronic properties of the Zn-II/Pt-II hexacation [(PtCl2)(CH3)(6)LZn](6+) in water solution were investigated using density functional theory (DFT) and time-dependent DFT (TDDFT) methods. TDDFT calculations of the lowest excited states of [(PtCl2)(CH3)(6)LZn](6+) in water provided an accurate description of the Qband spectral region. In particular, the calculated optical spectra were in agreement with the experimental ones, obtained in the presence of micelles favoring complete disruption of the aggregates. The model for dsDNA binding that emerges from the analysis of UV-vis absorption and time-resolved fluorescence data shows the presence of complexes of 1 dsDNA molecule with 1, 2, and 4 macrocycles. Comparing the results for the hexacation [(PtCl2)(CH3)(6)LZn](6+) with those for the [(CH3)(8)LZn](8+) foctacation, we observed a higher degree of monomerization for the [(PtCl2)(CH3)(6)LZn](6+) derivative. (literal)

Prodotto di

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Studio delle interazioni legando-recettore in sistemi modello mediante metodi spettroscopici e fotofisici (LEGARE) (PM.P06.005.002) (Modulo)
• Institute of Crystallography (IC) (Istituto)

Autore CNR

• FRANCESCO MANOLI (Persona)
• SANDRA MONTI (Unità di personale esterno)
• ANNALISA MASI (Unità di personale interno)
• ILSE GERT MANET (Unità di personale interno)

Incoming links:

Prodotto

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Institute of Crystallography (IC) (Istituto)
• Studio delle interazioni legando-recettore in sistemi modello mediante metodi spettroscopici e fotofisici (LEGARE) (PM.P06.005.002) (Modulo)

Autore CNR di

• ILSE GERT MANET (Unità di personale interno)
• FRANCESCO MANOLI (Persona)
• ANNALISA MASI (Unità di personale interno)
• SANDRA MONTI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Inorganic chemistry (Rivista)