beta-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study (Articolo in rivista)

Type
Label
  • beta-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1039/c2pp25014d (literal)
Alternative label
  • Anand, Resmi [ 1 ] ; Manoli, Francesco [ 1 ] ; Manet, Ilse [ 1 ] ; Daoud-Mahammed, Samia [ 2 ] ; Agostoni, Valentina [ 2 ] ; Gref, Ruxandra) 2 ] ; Monti, Sandra [ 1] (2012)
    beta-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study
    in Photochemical & photobiological sciences (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Anand, Resmi [ 1 ] ; Manoli, Francesco [ 1 ] ; Manet, Ilse [ 1 ] ; Daoud-Mahammed, Samia [ 2 ] ; Agostoni, Valentina [ 2 ] ; Gref, Ruxandra) 2 ] ; Monti, Sandra [ 1] (literal)
Pagina inizio
  • 1285 (literal)
Pagina fine
  • 1292 (literal)
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  • 11 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 8 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • [1] CNR, ISOF, I-40129 Bologna, Italy [ 2 ] Univ Paris 11, CNRS, UMR 8612, F-92296 Chatenay Malabry, France (literal)
Titolo
  • beta-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study (literal)
Abstract
  • The association of doxorubicin (DOX) and artemisinin (ART) to a beta-CyD-epichlorohydrin crosslinked polymer (p beta-CyD), organized in nanoparticles of ca. 15 nm size, was investigated in neutral aqueous medium by circular dichroism (CD), UV-vis absorption and fluorescence. The stability constants and the absolute CD spectra of the drug complexes were determined by global analysis of multiwavelength data from spectroscopic titrations. The polymer p beta-CyD proved able to disrupt the DOX dimer when the latter is the predominant form of DOX in solution. The spectroscopic and photophysical properties of the complexes evidenced an alcohol-like environment for ART and an improved inherent emission ability for DOX in the nanoparticle frame. (literal)
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