http://www.cnr.it/ontology/cnr/individuo/prodotto/ID209157
Altered stress responsiveness and hypothalamic-pituitary-adrenal axis function in male rat offspring of socially isolated parents. (Articolo in rivista)
- Type
- Label
- Altered stress responsiveness and hypothalamic-pituitary-adrenal axis function in male rat offspring of socially isolated parents. (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1111/jnc.12273 (literal)
- Alternative label
Pisu MG, Garau A, Olla P, Biggio F, Utzeri C, Dore R, Serra M. (2013)
Altered stress responsiveness and hypothalamic-pituitary-adrenal axis function in male rat offspring of socially isolated parents.
in Journal of neurochemistry (Online)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pisu MG, Garau A, Olla P, Biggio F, Utzeri C, Dore R, Serra M. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://onlinelibrary.wiley.com/doi/10.1111/jnc.12273/abstract;jsessionid=1C41FF3A22F31B13F1BD603BAF9B5F55.f02t02 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- C.N.R., Institute of Neuroscience, Cagliari, Italy; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy; Center of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari, Italy (literal)
- Titolo
- Altered stress responsiveness and hypothalamic-pituitary-adrenal axis function in male rat offspring of socially isolated parents. (literal)
- Abstract
- Social isolation in male rats at weaning results in reduced
basal levels of the neuroactive steroid 3a,5a-tetrahydroprogesterone
(3a,5a-TH PROG) in the brain and plasma as well
as increased anxiety-like behavior. We now show that socially
isolated female rats also manifest a reduced basal cerebrocortical
concentration of 3a,5a-TH PROG as well as an
anxiety-like pro?le in the elevated plus-maze and Vogel
con?ict tests compared with group-housed controls. In contrast,
despite the fact that they were raised under normal
conditions, adult male offspring of male and female rats
subjected to social isolation before mating exhibited an
increased basal cerebrocortical level of 3a,5a-TH PROG but
no difference in emotional reactivity compared with the
offspring of group-housed parents. These animals also
showed an increased basal activity of the hypothalamicpituitary-
adrenal axis as well as reduced abundance of
corticotropin-releasing factor in the hypothalamus and of
corticotropin-releasing factor receptor type 1 in the pituitary.
Moreover, negative feedback regulation of hypothalamicpituitary-
adrenal axis activity by glucocorticoid was enhanced
in association with up-regulation of glucocorticoid receptor
expression in the hippocampus. There was also attenuation of
corticosterone release induced by foot-shock stress in the
offspring of socially isolated parents. The increase in the brain
concentration of 3a,5a-TH PROG induced by acute stress was
also blunted in these animals. Our results thus show that a
stressful experience before mating can in?uence neuroendocrine
signaling in the next generation.
Keywords: 3a,5a-tetrahydroprogesterone, glucocorticoid receptor,
HPA axis, rat, socially isolated offspring, stress. (literal)
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