Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement. (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Alternative label

• Basolo F. 1, Giannini R. 1, Toniolo A. 4, Casalone R. 4, Nikiforova M. 6, Pacini F. 2, Elisei R. 2, Miccoli P.3, Berti P. 3, Faviana P. 1, Fiore L. 1, Monaco C. 5, Pierantoni G. M. 5, Fedele M. 5, Nikiforov Ye 6, Santoro M. 5, Fusco A. 5 (2002)
  Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement.
  in International journal of cancer (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Basolo F. 1, Giannini R. 1, Toniolo A. 4, Casalone R. 4, Nikiforova M. 6, Pacini F. 2, Elisei R. 2, Miccoli P.3, Berti P. 3, Faviana P. 1, Fiore L. 1, Monaco C. 5, Pierantoni G. M. 5, Fedele M. 5, Nikiforov Ye 6, Santoro M. 5, Fusco A. 5 (literal)

Pagina inizio

• 608 (literal)

Pagina fine

• 614 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 97 (literal)

Rivista

• International journal of cancer (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement. (literal)

Abstract

• A novel human thyroid papillary carcinoma cell line (FB-2) has been established and characterized. FB-2 cells harbor the RET/PTC1 chimeric oncogene in which the RET kinase domain is fused to the H4 gene. FB-2 cells neither formed colonies in semisolid media nor induced tumors after heterotransplant into severe combined immunodeficient mice. However, HMGI(Y), HMGI-C and c-myc genes, which are associated to thyroid cell transformation, were abundantly expressed in FB-2 cells but not in normal thyroid cells. FB-2 cells only partially retained the differentiated thyroid phenotype. In fact, the PAX-8 gene, which codes for a transcriptional factor required for thyroid cell differentiation, was expressed, while thyroglobulin, TSH-receptor and thyroperoxidase genes were not. Moreover, FB-2 cells produced high levels of interleukin (IL)-6 and IL-8. (literal)

Prodotto di

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Ruolo delle proteine cromatiniche nella tumorigenesi (SV.P15.001.002) (Modulo)

Autore CNR

• MASSIMO SANTORO (Unità di personale interno)
• ALFREDO FUSCO (Unità di personale interno)
• MONICA FEDELE (Persona)

Incoming links:

Autore CNR di

• ALFREDO FUSCO (Unità di personale interno)
• MONICA FEDELE (Persona)
• MASSIMO SANTORO (Unità di personale interno)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Ruolo delle proteine cromatiniche nella tumorigenesi (SV.P15.001.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• International journal of cancer (Rivista)