Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. (Articolo in rivista) (literal)

Anno

• 2001-01-01T00:00:00+01:00 (literal)

Alternative label

• Baldassarre G. 1, Fedele M. 1-2, Battista S. 1-2, Vecchione A. 1, Klein-Szanto A.J. 3, Santoro M. 2, Waldmann T.A. 4, Azimi N. 4, Croce C.M. 1, Fusco A. 1-2-5 (2001)
  Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway.
  in Proceedings of the National Academy of Sciences of the United States of America
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Baldassarre G. 1, Fedele M. 1-2, Battista S. 1-2, Vecchione A. 1, Klein-Szanto A.J. 3, Santoro M. 2, Waldmann T.A. 4, Azimi N. 4, Croce C.M. 1, Fusco A. 1-2-5 (literal)

Pagina inizio

• 7970 (literal)

Pagina fine

• 7975 (literal)

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• Impact Factor = 10,986 Interdisciplinarietà del prodotto: The Authors belong to different scientific areas, sectors and Istitutions. The paper was in collaboration with International Institutions. (literal)

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• 98 (literal)

Rivista

• Proceedings of the National Academy of Sciences of the United States of America (Rivista)

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• Rearrangements of the high mobility group protein I-C (HMGI-C) gene, consisting in the loss of the carboxyl-terminal tail, have been frequently detected in benign human tumors of mesenchymal origin. We have previously demonstrated that transgenic (TG) mice carrying a truncated HMGI-C construct (HMGI-C/T) exhibit a giant phenotype together with a predominantly abdominal/pelvic lipomatosis. Here, we report that HMGI-C/T TG mice develop natural killer (NK)-T/NK cell lymphomas starting from 12 months of age. We found an increased expression of IL-2 and IL-15 proteins and their receptors in these lymphomas, and we demonstrate that HMGI-C/T protein positively regulates their expression in vitro. Therefore, the HMGI-C/T-mediated chronic stimulation of the IL-2/IL-15 pathway could be responsible for the onset of NK-T/NK cell lymphomas in HMGI-C/T TG mice. (literal)

Note

• ISI Web of Science (WOS) (literal)

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• 1 Kimmel Cancer Center, Jefferson Medical College, Philadelphia USA; 2 Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli \"Federico II,\" Italy; 3 Experimental Histopathology, Fox-Chase Cancer Center, Philadelphia USA; 4 Metabolism Branch, Center for Cancer Research, NCI, NIH Bethesda USA; 5 Dipartimento di Medicina Sperimentale e Clinica Università di Catanzaro Italy (literal)

Titolo

• Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. (literal)

Abstract

• Rearrangements of the high mobility group protein I-C (HMGI-C) gene, consisting in the loss of the carboxyl-terminal tail, have been frequently detected in benign human tumors of mesenchymal origin. We have previously demonstrated that transgenic (TG) mice carrying a truncated HMGI-C construct (HMGI-C/T) exhibit a giant phenotype together with a predominantly abdominal/pelvic lipomatosis. Here, we report that HMGI-C/T TG mice develop natural killer (NK)-T/NK cell lymphomas starting from 12 months of age. We found an increased expression of IL-2 and IL-15 proteins and their receptors in these lymphomas, and we demonstrate that HMGI-C/T protein positively regulates their expression in vitro. Therefore, the HMGI-C/T-mediated chronic stimulation of the IL-2/IL-15 pathway could be responsible for the onset of NK-T/NK cell lymphomas in HMGI-C/T TG mice. (literal)

Prodotto di

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• MASSIMO SANTORO (Unità di personale interno)
• ALFREDO FUSCO (Unità di personale interno)
• MONICA FEDELE (Persona)
• SABRINA BATTISTA (Unità di personale interno)

Incoming links:

Autore CNR di

• ALFREDO FUSCO (Unità di personale interno)
• MONICA FEDELE (Persona)
• SABRINA BATTISTA (Unità di personale interno)
• MASSIMO SANTORO (Unità di personale interno)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Proceedings of the National Academy of Sciences of the United States of America (Rivista)