Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes (Articolo in rivista)

Type
Label
  • Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/sj.onc.1206112 (literal)
Alternative label
  • Castellone M.D. , Cirafici A.M. , De Vita G. , De Falco V. , Malorni L. , Tallini G. , Fagin J.A., Fusco A. , Melillo R.M. , Santoro M. (2003)
    Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes
    in Oncogene (Basingstoke)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Castellone M.D. , Cirafici A.M. , De Vita G. , De Falco V. , Malorni L. , Tallini G. , Fagin J.A., Fusco A. , Melillo R.M. , Santoro M. (literal)
Pagina inizio
  • 246 (literal)
Pagina fine
  • 255 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 22 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
  • SCImago (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Castellone M.D:Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II', Naples, Italy Cirafici A.M. Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II', Naples, Italy De Vita G:Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II', Naples, Italy De Falco V.:Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II', Naples, Italy Malorni L.:Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II', Naples, Italy Tallini G:Department of Pathology, University of Yale, USA Fagin J.A.:Division of Endocrinology, University of Cincinnati College of Medicine, Ohio 45267-0547, USA Fusco A.:Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II', Naples, Italy Melillo R.M.:Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II', Naples, Italy Santoro M.:Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II', Naples, Italy :Department of Pathology, University of Yale, USA (literal)
Titolo
  • Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes (literal)
Abstract
  • RET gene rearrangements, which generate chimeric RET/PTC oncogenes, are early events in the evolution of thyroid papillary carcinomas. Expression of RET/PTC oncogenes promotes neoplastic transformation of cultured thyroid cells and of thyroid glands in transgenic mice. Notwithstanding these oncogenic effects, we have found that the expression of two RET/PTC oncogenes (H4-RET and RFG-RET) induces apoptosis of rat thyroid PC CL 3 cells. Promotion of thyroid cell death depends on the kinase activity of RET/PTC and on the phosphorylation of a tyrosine residue (tyrosine 1062) that maps in the carboxy-terminus of the RET protein. Tyrosine 1062 is essential for RET/PTC-mediated activation of the Ras/ERK pathway. Inhibition of Ras/ERK by a dominant negative Ras or by the MEKI inhibitor, PD98059, obstructed RET/PTC-mediated apoptosis. We also show that signals transmitted by tyrosine 1062 mediate proapoptotic events like Bcl-2 down regulation and Bax upregulation, and that adoptive overexpression of Bcl-2 overcomes RET/PTC-induced apoptosis. Thus, gene rearrangements that generate RET/PTC oncogenes subvert RET function by converting it into a chronically active kinase that is constitutively phosphorylated on tyrosine 1062. In turn, Y1062 phosphorylation transmits not only mitogenic but also proapoptotic signals to thyroid cells. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it