Affinity, Speciation, and Molecular Features of Copper(II) Complexes with a Prion Tetraoctarepeat Domain in Aqueous Solution: Insights into Old and New Results (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Affinity, Speciation, and Molecular Features of Copper(II) Complexes with a Prion Tetraoctarepeat Domain in Aqueous Solution: Insights into Old and New Results (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/chem.201202912 (literal)

Alternative label

• Giuseppe Di Natale,[a] Katalin Osz,[b] Csilla Ka?llay,[c] Giuseppe Pappalardo,[a]Daniele Sanna,[d] Giuseppe Impellizzeri,[e] Imre So?va?go?,*[f] and Enrico Rizzarelli*[a, e] (2013)
  Affinity, Speciation, and Molecular Features of Copper(II) Complexes with a Prion Tetraoctarepeat Domain in Aqueous Solution: Insights into Old and New Results
  in Chemistry - A European Journal
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Giuseppe Di Natale,[a] Katalin Osz,[b] Csilla Ka?llay,[c] Giuseppe Pappalardo,[a]Daniele Sanna,[d] Giuseppe Impellizzeri,[e] Imre So?va?go?,*[f] and Enrico Rizzarelli*[a, e] (literal)

Pagina inizio

• 3751 (literal)

Pagina fine

• 3761 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 19 (literal)

Rivista

• Chemistry - A European Journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• [a] Dr. G. Di Natale, Dr. G. Pappalardo, Prof. E. Rizzarelli CNR Institute of Biostructures and Bioimaging V.le A. Doria 6, 95125 Catania (Italy) [b] Dr. K. Osz Department of Physical Chemistry University of Debrecen, 4010 Debrecen (Hungary) [c] Dr. C. Ka?llay MTA-DE Research Group on Homogeneous Catalysis and Reaction Mechanisms, Debrecen (Hungary) [d] Dr. D. Sanna CNR Institute of Biomolecular Chemistry, Traverse La Crucca 3 07040 Baldinca-Li Punti (SS) (Italy) [e] Prof. G. Impellizzeri, Prof. E. Rizzarelli Department of Chemical Sciences University of Catania, V.le A. Doria 6, 95125 Catania (Italy) E-mail: erizzarelli@unict.it [f] Prof. I. Sova?go? Department of Inorganic and Analytical Chemistry University of Debrecen, 4010 Debrecen (Hungary) E-mail: sovago@science.unideb.hu (literal)

Titolo

• Affinity, Speciation, and Molecular Features of Copper(II) Complexes with a Prion Tetraoctarepeat Domain in Aqueous Solution: Insights into Old and New Results (literal)

Abstract

• Characterization of the copper(II) complexes formed with the tetraoctarepeat peptide at low and high metal-to-ligand ratios and in a large pH range, would provide a breakthrough in the interpretation of biological relevance of the different metal complexes of copper(II)-tetraoctarepeat system. In the present work, the potentiometric, UV/Vis, circular dichroism (CD), and electron paramagnetic resonance (EPR) studies were carried out on copper(II) complexes with a PEG-ylated derivative of the tetraoctarepeats peptide sequence (Ac- PEG27-(PHGGGWGQ)4-NH2) and the peptide Ac-(PHGGGWGQ)2-NH2. Conjugation of tetraoctarepeat peptide sequence with polyethyleneglycol improved the solubility of the copper(II) complexes. The results enable a straightACHTUNGTRENUNGforward explanation of the conflicting results originated from the underestimation of all metal-ligand equilibria and the ensuing speciation. A complete and reliable speciation is therefore obtained with the released affinity and binding details of the main complexes species formed in aqueous solution. The results contribute to clarify the discrepancies of several studies in which the authors ascribe the redox activity of copper(II)-tetraoctarepeat system considering only the average effects of several coexisting species with very different stoichiometries and binding modes. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Caratterizzazione di complessi metallici formati da proteine coinvolte in patologie correlate al disordine conformazionale proteico. (PM.P01.004.002) (Modulo)

Autore CNR

• GIUSEPPE PAPPALARDO (Unità di personale interno)
• GIUSEPPE DI NATALE (Unità di personale interno)
• ENRICO RIZZARELLI (Unità di personale esterno)
• DANIELE SANNA (Persona)

Incoming links:

Autore CNR di

• GIUSEPPE PAPPALARDO (Unità di personale interno)
• DANIELE SANNA (Persona)
• ENRICO RIZZARELLI (Unità di personale esterno)
• GIUSEPPE DI NATALE (Unità di personale interno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Caratterizzazione di complessi metallici formati da proteine coinvolte in patologie correlate al disordine conformazionale proteico. (PM.P01.004.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Chemistry - A European Journal (Rivista)