Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1155/2013/652735 (literal)

Alternative label

• Stefania Lucia Nori, Maria Luisa Rocco, Fulvio Florenzano, Maria Teresa Ciotti, Luigi Aloe, and Luigi Manni (2013)
  Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture
  in Evidence-based complementary and alternative medicine (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Stefania Lucia Nori, Maria Luisa Rocco, Fulvio Florenzano, Maria Teresa Ciotti, Luigi Aloe, and Luigi Manni (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Article ID 652735 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.hindawi.com/journals/ecam/2013/652735/ (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 2013 (literal)

Rivista

• Evidence-based complementary and alternative medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 15 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Pharmaceutical and Biomedical Sciences (FARMABIOMED) Nanomates, University of Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy Institute of Cellular Biology and Neurobiology, National Research Council (CNR), Via del Fosso di Fiorano 64, 00143 Rome, Italy Confocal Microscopy Unit, European Brain Research Institute (EBRI), Institute of Cellular Biology and Neurobiology, National Research Council (CNR), Via del Fosso di Fiorano 64, 00143 Rome, Italy Institute of Translational Pharmacology, National Research Council (CNR), Via del Fosso del Cavaliere 100, 00133 Rome, Italy (literal)

Titolo

• Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture (literal)

Abstract

• Diabetic polyneuropathy (DPN), characterized by early hyperalgesia and increased nerve growth factor (NGF), evolves in late irreversible neuropathic symptoms with reduced NGF support to sensory neurons. Electroacupuncture (EA) modulates NGF in the peripheral nervous system, being effective for the treatment of DPN symptoms. We hypothesize that NGF plays an important pathogenic role in DPN development, while EA could be useful in the therapy of DPN by modulating NGF expression/activity. Diabetes was induced in rats by streptozotocin (STZ) injection. One week after STZ, EA was started and continued for three weeks. NGF system and hyperalgesia-related mediators were analyzed in the dorsal root ganglia (DRG) and in their spinal cord and skin innervation territories. Our results show that four weeks long diabetes increased NGF and NGF receptors and deregulated intracellular signaling mediators of DRG neurons hypersensitization; EA in diabetic rats decreased NGF and NGF receptors, normalized c-Jun N-terminal and p38 kinases activation, decreased transient receptor potential vanilloid-1 ion channel, and possibly activated the nuclear factor kappa-light-chain-enhancer of activated B cells (Nf-?B). In conclusion, NGF signaling deregulation might play an important role in the development of DPN. EA represents a supportive tool to control DPN development by modulating NGF signaling in diabetes-targeted neurons. (literal)

Prodotto di

• Traslazionalità di approcci terapeutici integrativi (ME.P04.009.004) (Modulo)

Autore CNR

• LUIGI MANNI (Unità di personale interno)
• FULVIO FLORENZANO (Unità di personale esterno)
• LUIGI ALOE (Unità di personale esterno)
• MARIA TERESA CIOTTI (Persona)
• Maria Luisa Rocco (Persona)

Incoming links:

Autore CNR di

• LUIGI MANNI (Unità di personale interno)
• MARIA TERESA CIOTTI (Persona)
• FULVIO FLORENZANO (Unità di personale esterno)
• Maria Luisa Rocco (Persona)
• LUIGI ALOE (Unità di personale esterno)

Prodotto

• Traslazionalità di approcci terapeutici integrativi (ME.P04.009.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Evidence-based complementary and alternative medicine (Rivista)