http://www.cnr.it/ontology/cnr/individuo/prodotto/ID20855
The RFG oligomerization domain mediates kinase activation and re-localization of the RET/PTC3 oncoprotein to the plasma membrane (Articolo in rivista)
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- Label
- The RFG oligomerization domain mediates kinase activation and re-localization of the RET/PTC3 oncoprotein to the plasma membrane (Articolo in rivista) (literal)
- Anno
- 2001-01-01T00:00:00+01:00 (literal)
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- Monaco C; Visconti R; Barone MV; Pierantoni GM; Berlingieri MT; De Lorenzo C; Mineo A; Vecchio G; Fusco A; Santoro M (literal)
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- ISI Web of Science (WOS) (literal)
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- C. Monaco; M. V. Barone; G. M. Pierantoni; M. T. Berlingieri; G. Vecchio; M. Santoro= Centro di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli 'Federico II', Italy
C. De Lorenzo= Department of Organic and Biological Chemistry, Università di Napoli 'Federico II', Italy
A. Mineo= Fondazione Senatore Pascale, Naples, Italy
A. Fusco= Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro, Italy (literal)
- Titolo
- The RFG oligomerization domain mediates kinase activation and re-localization of the RET/PTC3 oncoprotein to the plasma membrane (literal)
- Abstract
- The RET/PTC3 oncogene arises from the fusion between the N-terminal encoding domain of the RFG gene and the tyrosine kinase encoding domain of RET receptor. RET/PTC3 is very frequent in papillary thyroid carcinomas, especially in children exposed to the Chernobyl accident. We have studied the functional consequences of the RFG-RET fusion. Here we show that the N-terminal coiled-coil domain of RGF mediates oligomerization and activation of the kinase and of the transforming capability of RET/PTC3. In addition, the RFG coiled-coil domain mediates a physical association between RET/PTC3 and RGF proteins, rendering RFG a bona fide substrate of RET/PTC3 kinase. Finally, we show that the coiled-coil domain of RGF is essential for the distribution of the RET/PTC3 protein at the membrane/particulate cell compartment level, where also most of the RFG protein is localized. We propose that fusion to the RFG coiled-coil domain provides RET kinase with a scaffold that mediates oligomerization and re-localization of the RET/PTC3 protein, a process that may be crucial for the signalling of this specific RET/PTC variant. (literal)
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