Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach (Articolo in rivista)

Type
Label
  • Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1371/journal.pone.0058892 (literal)
Alternative label
  • Giusy Daniela Albano1,2., Caterina Di Sano1., Anna Bonanno1, Loredana Riccobono1, Rosalia Gagliardo1, Pascal Chanez3,4, Mark Gjomarkaj1, Angela Marina Montalbano1, Giulia Anzalone1, Stefania La Grutta1,5, Fabio Luigi Massimo Ricciardolo6, Mirella Profita1* (2013)
    Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach
    in PloS one
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Giusy Daniela Albano1,2., Caterina Di Sano1., Anna Bonanno1, Loredana Riccobono1, Rosalia Gagliardo1, Pascal Chanez3,4, Mark Gjomarkaj1, Angela Marina Montalbano1, Giulia Anzalone1, Stefania La Grutta1,5, Fabio Luigi Massimo Ricciardolo6, Mirella Profita1* (literal)
Pagina inizio
  • 1 (literal)
Pagina fine
  • 13 (literal)
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  • 8 (literal)
Rivista
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  • 13 (literal)
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  • 4 (literal)
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Unit: '' Ex vivo/In vitro models to study the Immunopathology and the Pharmacology of airway diseases'', Institute of Biomedicine and Molecular Immunology, Italian National Research Council, Palermo, Italy, 2 Dipartimento Biomedico di Medicina, Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy, 3 Departement des Maladies Respiratoires, AP-HM, Universite´ de la Mediterranee, Marseille, France, 4 INSERM-CNRS U600, UMR6212, Universite´ de la Mediterranee, Marseille, France, 5 Environmental Health Unit, ARPA Palermo, Palermo, Italy, 6 Division of Respiratory Disease, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy (literal)
Titolo
  • Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach (literal)
Abstract
  • Th17 cells and IL-17A play a role in the development and progression of allergic diseases. We analyzed the IL-17A levels in sputum supernatants (Ss), nasal wash (NW) and plasma (P) from Healthy Controls (HC) and children with Asthma/Rhinitis. We tested the expression of IL-17A, RORc(t) and FOXP3 in peripheral blood T-lymphocytes from intermittent and mildmoderate asthma. The effect of Budesonide and Formoterol was tested ''in vitro'' on IL-17A, RORc(t) and FOXP3 expression in cultured T-lymphocytes from mild-moderate asthma/persistent rhinitis patients, and on nasal and bronchial epithelial cells stimulated with NW and Ss from mild-moderate asthma/persistent rhinitis. Further, the effect of 12 weeks of treatment with Budesonide and Formoterol was tested ''in vivo'' in T-lymphocytes from mild-moderate asthma/persistent rhinitis patients. IL-17A was increased in Ss, NW and P from children with mild-moderate asthma compared with intermittent and HC. In cultured T-lymphocytes IL-17A and RORc(t) expression were higher in mild-moderate asthma/persistent rhinitis than in mild-moderate asthma/intermittent rhinitis, while FOXP3 was reduced. Budesonide with Formoterol reduced IL-17A and RORc(t), while increased FOXP3 in cultured T-lymphocytes from mild-moderate asthma/persistent rhinitis, and reduced the IL-8 release mediated by IL-17A present in NW and Ss from mild-moderate asthma/persistent rhinitis in nasal and bronchial epithelial cells. Finally, Budesonide with Formoterol reduced IL-17A levels in P and Ss, CD4+IL-17A+T-cells, in na?ve children with mild-moderate asthma/persistent rhinitis after 12 weeks of treatment. Th17 mediated immunity may be involved in the airway disease of children with allergic asthma and allergic rhinitis. Budesonide with Formoterol might be a useful tool for its therapeutic control. (literal)
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