http://www.cnr.it/ontology/cnr/individuo/prodotto/ID208354
Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach (Articolo in rivista)
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- Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1371/journal.pone.0058892 (literal)
- Alternative label
Giusy Daniela Albano1,2., Caterina Di Sano1., Anna Bonanno1, Loredana Riccobono1, Rosalia Gagliardo1,
Pascal Chanez3,4, Mark Gjomarkaj1, Angela Marina Montalbano1, Giulia Anzalone1, Stefania La Grutta1,5,
Fabio Luigi Massimo Ricciardolo6, Mirella Profita1* (2013)
Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach
in PloS one
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Giusy Daniela Albano1,2., Caterina Di Sano1., Anna Bonanno1, Loredana Riccobono1, Rosalia Gagliardo1,
Pascal Chanez3,4, Mark Gjomarkaj1, Angela Marina Montalbano1, Giulia Anzalone1, Stefania La Grutta1,5,
Fabio Luigi Massimo Ricciardolo6, Mirella Profita1* (literal)
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- 1 Unit: '' Ex vivo/In vitro models to study the Immunopathology and the Pharmacology of airway diseases'', Institute of Biomedicine and Molecular Immunology, Italian National Research Council, Palermo, Italy,
2 Dipartimento Biomedico di Medicina, Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy,
3 Departement des Maladies Respiratoires, AP-HM, Universite´ de la Mediterranee, Marseille, France,
4 INSERM-CNRS U600, UMR6212, Universite´ de la Mediterranee, Marseille, France,
5 Environmental Health Unit, ARPA Palermo, Palermo, Italy,
6 Division of Respiratory Disease, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy (literal)
- Titolo
- Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach (literal)
- Abstract
- Th17 cells and IL-17A play a role in the development and progression of allergic diseases. We analyzed the IL-17A levels in sputum supernatants (Ss), nasal wash (NW) and plasma (P) from Healthy Controls (HC) and children with Asthma/Rhinitis. We tested the expression of IL-17A, RORc(t) and FOXP3 in peripheral blood T-lymphocytes from intermittent and mildmoderate asthma. The effect of Budesonide and Formoterol was tested ''in vitro'' on IL-17A, RORc(t) and FOXP3 expression in cultured T-lymphocytes from mild-moderate asthma/persistent rhinitis patients, and on nasal and bronchial epithelial cells stimulated with NW and Ss from mild-moderate asthma/persistent rhinitis. Further, the effect of 12 weeks of treatment with Budesonide and Formoterol was tested ''in vivo'' in T-lymphocytes from mild-moderate asthma/persistent rhinitis patients. IL-17A was increased in Ss, NW and P from children with mild-moderate asthma compared with intermittent and HC. In cultured T-lymphocytes IL-17A and RORc(t) expression were higher in mild-moderate asthma/persistent rhinitis than in mild-moderate asthma/intermittent rhinitis, while FOXP3 was reduced. Budesonide with Formoterol reduced IL-17A and RORc(t), while increased FOXP3 in cultured T-lymphocytes from mild-moderate asthma/persistent rhinitis, and reduced the IL-8 release mediated by IL-17A present in NW and Ss from mild-moderate asthma/persistent rhinitis in nasal and bronchial epithelial cells. Finally, Budesonide with Formoterol reduced IL-17A levels in P and Ss, CD4+IL-17A+T-cells, in na?ve children with mild-moderate asthma/persistent rhinitis after 12 weeks of treatment. Th17 mediated immunity may be involved in the airway disease of children with allergic asthma and allergic rhinitis. Budesonide with Formoterol might be a useful tool for its therapeutic control. (literal)
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