Know Your Current I-h: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Know Your Current I-h: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1371/journal.pone.0036867 (literal)

Alternative label

• Migliore M; Migliore R (2012)
  Know Your Current I-h: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations
  in PloS one; Public Library of Science, San Francisco (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Migliore M; Migliore R (literal)

Pagina inizio

• e36867 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0036867 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• PloS one (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR, Inst Biophys, Palermo, Italy (literal)

Titolo

• Know Your Current I-h: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations (literal)

Abstract

• The non-specific, hyperpolarization activated, Ih current is particularly involved in epilepsy and it exhibits an excitatory or inhibitory action on synaptic integration in an apparently inconsistent way. It has been suggested that most of the inconsistencies could be reconciled invoking an indirect interaction with the M-type K+ current, another current involved in epilepsy. However, here we show that the original experiments, and the simplified model used to explain and support them, cannot explain in a conclusive way the puzzling Ih actions observed in different experimental preparations. Using a realistic model, we show instead how and why a shunting current, such as that carried by TASK-like channels, and dependent on Ih channel is able to explain virtually all experimental findings on Ih up- or down-regulation by modulators or pathological conditions. The model results suggest several experimentally testable predictions to characterize in more details this elusive and peculiar interaction, which may be of fundamental importance in the development of new treatments for all those pathological and cognitive dysfunctions caused, mediated, or affected by Ih. (literal)

Editore

• Public Library of Science (Editore)

Prodotto di

• Istituto di biofisica (IBF) (Istituto)
• Modelli di Organizzazione e Dinamica di Sistemi Complessi (MD.P01.004.001) (Modulo)

Autore CNR

• MICHELE MIGLIORE (Unità di personale interno)
• ROSANNA MIGLIORE (Persona)

Insieme di parole chiave

• Keywords of "Know Your Current I-h: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biofisica (IBF) (Istituto)
• Modelli di Organizzazione e Dinamica di Sistemi Complessi (MD.P01.004.001) (Modulo)

Autore CNR di

• MICHELE MIGLIORE (Unità di personale interno)
• ROSANNA MIGLIORE (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• PloS one (Rivista)

Editore di

• Public Library of Science (Editore)

Insieme di parole chiave di

• Keywords of "Know Your Current I-h: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations" (Insieme di parole chiave)