Retinoic acid impairs estrogen signaling in breast cancer cells by interfering with activation of LSD1 via PKA (Articolo in rivista)

Type
Label
  • Retinoic acid impairs estrogen signaling in breast cancer cells by interfering with activation of LSD1 via PKA (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbagrm.2013.03.003 (literal)
Alternative label
  • Maria Neve Ombra a, Annalisa Di Santi b, Ciro Abbondanza b, Antimo Migliaccio b, Enrico Vittorio Avvedimento c, Bruno Perillo a. (2013)
    Retinoic acid impairs estrogen signaling in breast cancer cells by interfering with activation of LSD1 via PKA
    in Biochimica et biophysica acta. Gene regulatory mechanisms (Print); ELSEVIER, NEW YORK (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Maria Neve Ombra a, Annalisa Di Santi b, Ciro Abbondanza b, Antimo Migliaccio b, Enrico Vittorio Avvedimento c, Bruno Perillo a. (literal)
Pagina inizio
  • 480 (literal)
Pagina fine
  • 486 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://dx.doi.org/10.1016/j.bbagrm.2013.03.003 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1829 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5 (literal)
Note
  • PubMed (literal)
  • cience direct - Elsevier (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a Istituto di Scienze dell'Alimentazione, C.N.R., 83100 Avellino, Italy b Dipartimento di Patologia Generale, Seconda Universit√† degli Studi di Napoli, 80138 Naples, Italy c Dipartimento di Biologia e Patologia Cellulare e Molecolare \"L. Califano\", Universit√† degli Studi \"Federico II\", 80131 Naples, Italy (literal)
Titolo
  • Retinoic acid impairs estrogen signaling in breast cancer cells by interfering with activation of LSD1 via PKA (literal)
Abstract
  • More than 70% of breast cancers in women require estrogens for cell proliferation and survival. 17?-estradiol (E2) effect on mammary target cells is almost exclusively mediated by its binding to the estrogen receptor-? (ER?) that joins chromatin where it assembles active transcription complexes. The proliferative and pro-survival action of estrogens is antagonized in most cases by retinoic acid (RA), even though the cognate retinoic acid receptor-? (RAR?) cooperates with ER? on promoters of estrogen-responsive genes. We have examined at the molecular level the crosstalk between these nuclear receptors from the point of view of their control of cell growth and show here that RA reverts estrogen-stimulated transcription of the pivotal anti-apoptotic bcl-2 gene by preventing demethylation of dimethyl lysine 9 in histone H3 (HeK9me2). As we previously reported, this is obtained by means of E2-triggered activation of the lysine-specific demethylase 1 (LSD1), an enzyme that manages chromatin plasticity in order to allow specific movements of chromosomal regions within the nucleus. We find that E2 fuels LSD1 by inducing migration of the catalytic subunit of protein kinase A (PKA) into the nucleus, where it targets estrogen-responsive loci. RA rescues LSD1-dependent disappearance of H3K9me2 at bcl-2 regulatory regions upon the prevention of PKA assembly to the same sites. (literal)
Editore
Prodotto di
Autore CNR

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Editore di
data.CNR.it