Complexity of chromatin folding is captured by the strings and binders switch model (Articolo in rivista)

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  • Complexity of chromatin folding is captured by the strings and binders switch model (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1073/pnas.1204799109 (literal)
Alternative label
  • Mariano Barbieri a, Mita Chotalia b, James Fraser c, Liron-Mark Lavitas b, Josée Dostie c, Ana Pombo b, and Mario Nicodemi a (2012)
    Complexity of chromatin folding is captured by the strings and binders switch model
    in Proceedings of the National Academy of Sciences of the United States of America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mariano Barbieri a, Mita Chotalia b, James Fraser c, Liron-Mark Lavitas b, Josée Dostie c, Ana Pombo b, and Mario Nicodemi a (literal)
Pagina inizio
  • 16173 (literal)
Pagina fine
  • 16178 (literal)
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  • http://www.pnas.org/cgi/doi/10.1073/pnas.1204799109 (literal)
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  • 109 (literal)
Rivista
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  • 6 (literal)
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  • 40 (literal)
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  • a Dipartimento di Scienze Fisiche, Università di Napoli Federico II, and Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, Centro Nazionale delle Ricerche, Istituto SPIN, Complesso Universitario di Monte Sant'Angelo, 80126 Naples, Italy; b Genome Function Group, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, England; and c Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montréal, QC, Canada H3G 1Y6 (literal)
Titolo
  • Complexity of chromatin folding is captured by the strings and binders switch model (literal)
Abstract
  • Chromatin has a complex spatial organization in the cell nucleus that serves vital functional purposes. A variety of chromatin folding conformations has been detected by single-cell imaging and chromosome conformation capture-based approaches. However, a unified quantitative framework describing spatial chromatin organization is still lacking. Here, we explore the \"strings and binders switch\" model to explain the origin and variety of chromatin behaviors that coexist and dynamically change within living cells. This simple polymer model recapitulates the scaling properties of chromatin folding reported experimentally in different cellular systems, the fractal state of chromatin, the processes of domain formation, and looping out. Additionally, the strings and binders switch model reproduces the recently proposed \"fractal-globule\" model, but only as one of many possible transient conformations. (literal)
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