http://www.cnr.it/ontology/cnr/individuo/prodotto/ID2070
Charge transport and intrinsic fluorescence in amyloid-like fibrils (Articolo in rivista)
- Type
- Label
- Charge transport and intrinsic fluorescence in amyloid-like fibrils (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Alternative label
del Mercato, LL; Pompa, PP; Maruccio, G; Della Torre, A; Sabella, S; Tamburro, AM; Cingolani, R; Rinaldi, R (2007)
Charge transport and intrinsic fluorescence in amyloid-like fibrils
in Proceedings of the National Academy of Sciences of the United States of America
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- del Mercato, LL; Pompa, PP; Maruccio, G; Della Torre, A; Sabella, S; Tamburro, AM; Cingolani, R; Rinaldi, R (literal)
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- Rivista
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Univ Salento, Consiglio Nazl Ric, Ist Nazl Fis Mat, Natl Nanotechnol Lab, I-73100 Lecce, Italy; Univ Salento, Italian Inst Technol, Res Unit, Scuola Super ISUFI, I-73100 Lecce, Italy; Univ Basilicata, Dept Chem, I-85100 Potenza, Italy (literal)
- Titolo
- Charge transport and intrinsic fluorescence in amyloid-like fibrils (literal)
- Abstract
- The self-assembly of polypeptides into stable, conductive, and intrinsically fluorescent biomolecular nanowires is reported. We have studied the morphology and electrical conduction of fibrils made of an elastin-related polypeptide, poly(ValGlyGlyLeuGly). These amyloid-like nanofibrils, with a diameter ranging from 20 to 250 nm, result from self-assembly in aqueous solution at neutral pH. Their morphological properties and conductivity have been investigated by atomic force microscopy, scanning tunneling microscopy, and two-terminal transport experiments at the micro-and nanoscales. We demonstrate that the nanofibrils can sustain significant electrical conduction in the solid state at ambient conditions and have remarkable stability. We also show intrinsic blue-green fluorescence of the nanofibrils by confocal microscopy analyses. These results indicate that direct (label-free) excitation can be used to investigate the aggregation state or the polymorphism of amyloid-like fibrils (and possibly of other proteinaceous material) and open up interesting perspectives for the use of peptide-based nanowire structures, with tunable physical and chemical properties, for a wide range of nanobiotechnological and bioelectronic applications. (literal)
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