HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• Rinaldo C, Moncada A, Gradi A, Ciuffini L, D'Eliseo D, Siepi F, Prodosmo A, Giorgi A, Pierantoni GM, Trapasso F, Guarguaglini G, Bartolazzi A, Cundari E, Schininà ME, Fusco A, Soddu S. (2012)
  HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody.
  in Molecular cell
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Rinaldo C, Moncada A, Gradi A, Ciuffini L, D'Eliseo D, Siepi F, Prodosmo A, Giorgi A, Pierantoni GM, Trapasso F, Guarguaglini G, Bartolazzi A, Cundari E, Schininà ME, Fusco A, Soddu S. (literal)

Rivista

• Molecular cell (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli 80131, Italy. Laboratorio di Oncogenesi Molecolare, Dipartimento di Oncologia Sperimentale, Istituto Nazionale dei Tumori Regina Elena, 00158 Rome, Italy. rinaldo@ifo.it (literal)

Titolo

• HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody. (literal)

Abstract

• Failure in cytokinesis, the final step in cell division, by generating tetra- and polyploidization promotes chromosomal instability, a hallmark of cancer. Here we show that HIPK2, a kinase involved in cell fate decisions in development and response to stress, controls cytokinesis and prevents tetraploidization through its effects on histone H2B. HIPK2 binds and phosphorylates histone H2B at S14 (H2B-S14(P)), and the two proteins colocalize at the midbody. HIPK2 depletion by targeted gene disruption or RNA interference results in loss of H2B-S14(P) at the midbody, prevention of cell cleavage, and tetra- and polyploidization. In HIPK2 null cells, restoration of wild-type HIPK2 activity or expression of a phosphomimetic H2B-S14D derivative abolishes cytokinesis defects and rescues cell proliferation, showing that H2B-S14(P) is required for a faithful cytokinesis. Overall, our data uncover mechanisms of a critical HIPK2 function in cytokinesis and in the prevention of tetraploidization. (literal)

Prodotto di

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Ruolo delle proteine cromatiniche nella tumorigenesi (SV.P15.001.002) (Modulo)

Autore CNR

• GIULIA GUARGUAGLINI (Persona)
• ENRICO CUNDARI (Unità di personale interno)
• ALFREDO FUSCO (Unità di personale interno)
• CINZIA RINALDO (Persona)
• GIOVANNA MARIA PIERANTONI (Persona)

Incoming links:

Autore CNR di

• ALFREDO FUSCO (Unità di personale interno)
• GIULIA GUARGUAGLINI (Persona)
• ENRICO CUNDARI (Unità di personale interno)
• GIOVANNA MARIA PIERANTONI (Persona)
• CINZIA RINALDO (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Ruolo delle proteine cromatiniche nella tumorigenesi (SV.P15.001.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular cell (Rivista)